A nanoscale metal-organic framework for combined photodynamic and starvation therapy in treating breast tumors

被引：42

作者：

Guan, Qun ^{[1
]}

Zhou, Le-Le ^{[1
,2
]}

Li, Yan-An ^{[1
]}

Dong, Yu-Bin ^{[1
]}

机构：

[1] Shandong Normal Univ, Collaborat Innovat Ctr Functionalized Probes Chem, Coll Chem Chem Engn & Mat Sci, Key Lab Mol & Nano Probes,Minist Educ, Jinan 250014, Shandong, Peoples R China

[2] Qilu Inst Technol, Sch Chem & Biol Engn, Jinan 250200, Shandong, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 99期

关键词：

CANCER-CELLS; CO; MITOCHONDRIA; METABOLISM;

D O I：

10.1039/c9cc07510k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We demonstrate herein an effective cascade reaction for combined photodynamic and starvation therapy in treating breast tumors based on a photosensitizer and CO prodrug decorated NMOF. The PDT-induced ROS can further trigger CO release, and the high antitumor efficiency derived from both O-1(2) and CO is well confirmed by in vitro assays and in vivo trials.

引用

页码：14898 / 14901

页数：4

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