Streamlined EDSS for use in multiple sclerosis clinical practice: Development and cross-sectional comparison to EDSS

被引：10

作者：

Baldassari, Laura E. ^{[1
,2
]}

Salter, Amber R. ^{[3
]}

Longbrake, Erin E. ^{[1
,4
]}

Cross, Anne H. ^{[1
]}

Naismith, Robert T. ^{[1
]}

机构：

[1] Washington Univ St Louis, John L Trotter Multiple Sclerosis Ctr, Dept Neurol, Sch Med, 660 South Euclid Ave,Campus Box 8111, St Louis, MO 63110 USA

[2] Univ Utah Hlth, Div Neuroimmunol, Dept Neurol, Salt Lake City, UT USA

[3] Washington Univ St Louis, Div Biostat, Sch Med, St Louis, MO USA

[4] Yale Univ, Sch Med, Dept Neurol, New Haven, CT 06510 USA

来源：

MULTIPLE SCLEROSIS JOURNAL | 2018年 / 24卷 / 10期

关键词：

Multiple sclerosis; Expanded Disability Status Scale; disability; disability outcome measure; clinical scale; DISABILITY STATUS SCALE; MS; IMPAIRMENT;

D O I：

10.1177/1352458517721357

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: The Expanded Disability Status Scale (EDSS) is the standard measure of disability in multiple sclerosis clinical trials. The EDSS has limited application in the clinical setting due to required completion time and scoring complexity. Systematically recording an objective, simplified, less time-intensive, and neurologist-derived disability score would be beneficial for patient care. Objective: To develop and validate a streamlined version of the Expanded Disability Status Scale (sEDSS) for clinical monitoring. Methods: The EDSS was modified by eliminating maneuvers with no impact on function, consolidating redundancies, and simplifying scoring. This sEDSS was refined and preliminarily validated using a pilot cohort of 102 patients. Subsequently, the sEDSS was retrospectively validated using 968 patients from the CombiRx trial. We evaluated correlation and agreement between each functional system as well as the overall sEDSS and EDSS. Results: The sEDSS correlated strongly with the EDSS, both overall (Spearman's rho=0.93) and for each functional system (Spearman's rho 0.65-0.97). Correlation was slightly lower for functional systems where scoring was modified for consolidation and simplification. Conclusion: The sEDSS had strong agreement and correlation with the existing EDSS and can provide a useful measure of disability in clinical practice.

引用

页码：1347 / 1355

页数：9

共 16 条

[1]

Amato MP, 1999, MULT SCLER, V5, P216, DOI 10.1177/135245859900500404

[2]

Bland JM, 1999, STAT METHODS MED RES, V8, P135, DOI 10.1177/096228029900800204

[3] Self-administered Expanded Disability Status Scale with functional system scores correlates well with a physician-administered test [J].