Weak effects of common genetic variation in oxytocin and vasopressin receptor genes on rhesus macaque social behavior

被引:11
作者
Madlon-Kay, Seth [1 ]
Montague, Michael J. [1 ]
Brent, Lauren J. N. [2 ]
Ellis, Samuel [2 ]
Zhong, Brian [1 ]
Snyder-Mackler, Noah [3 ,4 ,5 ]
Horvath, Julie E. [6 ,7 ,8 ]
Skene, Jesse Haynes Pate [9 ]
Platt, Michael L. [10 ,11 ]
机构
[1] Univ Penn, Dept Neurosci, Perelman Sch Med, 3440 Market St,Suite 440, Philadelphia, PA 19104 USA
[2] Univ Exeter, Ctr Res Anim Behav, Exeter, Devon, England
[3] Univ Washington, Dept Psychol, Seattle, WA 98195 USA
[4] Univ Washington, Ctr Studies Demog & Ecol, Seattle, WA 98195 USA
[5] Univ Washington, Washington Natl Primate Res Ctr, Seattle, WA 98195 USA
[6] North Carolina Cent Univ, Dept Biol & Biomed Sci, Durham, NC 27707 USA
[7] North Carolina Museum Nat Sci, Raleigh, NC USA
[8] Duke Univ, Dept Evolutionary Anthropol, Durham, NC USA
[9] Duke Univ, Dept Neurobiol, Durham, NC USA
[10] Univ Penn, Dept Psychol, Sch Arts & Sci, 3815 Walnut St, Philadelphia, PA 19104 USA
[11] Univ Penn, Dept Mkt, Wharton Sch, Philadelphia, PA 19104 USA
基金
美国国家卫生研究院;
关键词
behavioral genetics; oxytocin; rhesus macaques; social behavior; vasopressin; GENOME-WIDE-ASSOCIATION; COMPLEX TRAITS; PERSONALITY-TRAITS; MACACA-MULATTA; HERITABILITY; AUTISM; OXTR; AVPR1A; LOCI; SNPS;
D O I
10.1002/ajp.22873
中图分类号
Q95 [动物学];
学科分类号
071002 ;
摘要
The neuropeptides oxytocin (OT) and arginine vasopressin (AVP) influence pair bonding, attachment, and sociality, as well as anxiety and stress responses in humans and other mammals. The effects of these peptides are mediated by genetic variability in their associated receptors, OXTR and the AVPR gene family. However, the role of these genes in regulating social behaviors in non-human primates is not well understood. To address this question, we examined whether genetic variation in the OT receptor gene OXTR and the AVP receptor genes AVPR1A and AVPR1B influence naturally-occurring social behavior in free-ranging rhesus macaquesgregarious primates that share many features of their biology and social behavior with humans. We assessed rates of social behavior across 3,250hr of observational behavioral data from 201 free-ranging rhesus macaques on Cayo Santiago island in Puerto Rico, and used genetic sequence data to identify 25 OXTR, AVPR1A, and AVPR1B single-nucleotide variants (SNVs) in the population. We used an animal model to estimate the effects of 12 SNVs (n=3 OXTR; n=5 AVPR1A; n=4 AVPR1B) on rates of grooming, approaches, passive contact, contact aggression, and non-contact aggression, given and received. Though we found evidence for modest heritability of these behaviors, estimates of effect sizes of the selected SNVs were close to zero, indicating that common OXTR and AVPR variation contributed little to social behavior in these animals. Our results are consistent with recent findings in human genetics that the effects of individual common genetic variants on complex phenotypes are generally small. We examined whether genetic variation in the OT receptor gene OXTR and the AVP receptor genes AVPR1A and AVPR1B influence naturally-occurring social behavior in free-ranging rhesus macaques. We measured rates of aggressive and affiliative behaviors across 3,250hr of observational behavioral data from free-ranging rhesus macaques on Cayo Santiago island. Using genetic sequence data, we identified 25 OXTR, AVPR1A, and AVPR1B single-nucleotide variants (SNVs) in 201 of the studied animals. Estimates of effect sizes of the selected SNVs were close to zero, indicating that common OXTR and AVPR variation contributed little to social behavior in these animals.
引用
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页数:12
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共 92 条
  • [21] A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3
    Cingolani, Pablo
    Platts, Adrian
    Wang, Le Lily
    Coon, Melissa
    Tung Nguyen
    Wang, Luan
    Land, Susan J.
    Lu, Xiangyi
    Ruden, Douglas M.
    [J]. FLY, 2012, 6 (02) : 80 - 92
  • [22] Oxytocin receptor polymorphisms and adult attachment style in patients with depression
    Costa, Barbara
    Pini, Stefano
    Gabelloni, Pamela
    Abelli, Marianna
    Lari, Lisa
    Cardini, Alessandra
    Muti, Matteo
    Gesi, Camilla
    Landi, Stefano
    Galderisi, Silvana
    Mucci, Armida
    Lucacchini, Antonio
    Cassano, Giovanni B.
    Martini, Claudia
    [J]. PSYCHONEUROENDOCRINOLOGY, 2009, 34 (10) : 1506 - 1514
  • [23] Genome-wide association studies establish that human intelligence is highly heritable and polygenic
    Davies, G.
    Tenesa, A.
    Payton, A.
    Yang, J.
    Harris, S. E.
    Liewald, D.
    Ke, X.
    Le Hellard, S.
    Christoforou, A.
    Luciano, M.
    McGhee, K.
    Lopez, L.
    Gow, A. J.
    Corley, J.
    Redmond, P.
    Fox, H. C.
    Haggarty, P.
    Whalley, L. J.
    McNeill, G.
    Goddard, M. E.
    Espeseth, T.
    Lundervold, A. J.
    Reinvang, I.
    Pickles, A.
    Steen, V. M.
    Ollier, W.
    Porteous, D. J.
    Horan, M.
    Starr, J. M.
    Pendleton, N.
    Visscher, P. M.
    Deary, I. J.
    [J]. MOLECULAR PSYCHIATRY, 2011, 16 (10) : 996 - 1005
  • [24] Estimating Trait Heritability in Highly Fecund Species
    Davies, Sarah W.
    Scarpino, Samuel V.
    Pongwarin, Thanapat
    Scott, James
    Matz, Mikhail V.
    [J]. G3-GENES GENOMES GENETICS, 2015, 5 (12): : 2639 - 2645
  • [25] Evidence of an association between the vasopressin V1b receptor gene (AVPR1B) and childhood-onset mood disorders
    Dempster, Emma L.
    Burcescu, Irina
    Wigg, Karen
    Kiss, Eniko
    Baji, Ildiko
    Gadoros, Julia
    Tamas, Zsuzsanna
    Kennedy, James L.
    Vetro, Agnes
    Kovacs, Maria
    Barr, Cathy L.
    [J]. ARCHIVES OF GENERAL PSYCHIATRY, 2007, 64 (10) : 1189 - 1195
  • [26] Allele frequency matching between SNPs reveals an excess of linkage disequilibrium in genic regions of the human genome
    Eberle, Michael A.
    Rieder, Mark J.
    Kruglyak, Leonid
    Nickerson, Deborah A.
    [J]. PLOS GENETICS, 2006, 2 (09): : 1319 - 1327
  • [27] The contributions of oxytocin and vasopressin pathway genes to human behavior
    Ebstein, Richard P.
    Knafo, Ariel
    Mankuta, David
    Chew, Soo Hong
    Lai, Poh San
    [J]. HORMONES AND BEHAVIOR, 2012, 61 (03) : 359 - 379
  • [28] FEDIGAN LM, 1983, YEARB PHYS ANTHROPOL, V26, P91
  • [29] Fisher Ronald A., 1918, T ROY SOC EDINBURGH, V52, P399, DOI DOI 10.1017/S0080456800012163
  • [30] Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications
    Freeman, Sara M.
    Young, Larry J.
    [J]. JOURNAL OF NEUROENDOCRINOLOGY, 2016, 28 (04)