Epigenome-wide association studies for systemic autoimmune diseases: The road behind and the road ahead

被引：14

作者：

Carnero-Montoro, Elena ^{[1
]}

Alarcon-Riquelme, Marta E. ^{[1
,2
]}

机构：

[1] Univ Granada, Pfizer, Andalusian Govt Ctr Genom & Oncol Res GENYO, Granada, Spain

[2] Karolinska Inst, Inst Environm Med, Unit Inflammatory Chron Dis, Solna, Sweden

来源：

CLINICAL IMMUNOLOGY | 2018年 / 196卷

关键词：

NAIVE CD4+T CELLS; PRIMARY SJOGRENS-SYNDROME; DNA METHYLATION; RHEUMATOID-ARTHRITIS; LUPUS-ERYTHEMATOSUS; T-CELLS; EPIGENETIC SIGNATURES; GENE-EXPRESSION; HETEROGENEITY; WOMEN;

D O I：

10.1016/j.clim.2018.03.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Epigenetics is known to be an important mechanism in the pathogenesis of autoimmune diseases. Epigenetic variations can act as integrators of environmental and genetic exposures and propagate activated states in immune cells. Studying epigenetic alterations by means of genome-wide approaches promises to unravel novel molecular mechanisms related to disease etiology, disease progression, clinical manifestations and treatment responses. This paper reviews what we have learned in the last five years from epigenome-wide studies for three systemic autoimmune diseases, namely systemic lupus erythematosus, primary Sjogren's syndrome, and rheumatoid arthritis. We examine the degree of epigenetic sharing between different diseases and the possible mediating role of epigenetic associations in genetic and environmental risks. Finally, we also shed light into the use of epigenetic markers towards a better precision medicine regarding disease prediction, prevention and personalized treatment in systemic autoimmunity.

引用

页码：21 / 33

页数：13

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