Redox-Neutral Indole Annulation Cascades

被引：178

作者：

Haibach, Michael C. ^{[1
]}

Deb, Indubhusan ^{[1
]}

De, Chandra Kanta ^{[1
]}

Seidel, Daniel ^{[1
]}

机构：

[1] Rutgers State Univ, Dept Chem & Chem Biol, Piscataway, NJ 08854 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 07期

基金：

美国国家科学基金会;

关键词：

C-H BOND; RING-CLOSURE REACTIONS; NITROGEN-CONTAINING HETEROCYCLES; ONE-POT SYNTHESIS; INTERMOLECULAR REACTIONS; CYCLOADDITION REACTION; CATALYZED CYCLIZATION; 1,5-HYDRIDE SHIFTS; ORGANIC-SYNTHESIS; ALKYNYL ETHERS;

D O I：

10.1021/ja110713k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Aminobenzaldehydes react with indoles in an unprecedented cascade reaction. This acid-catalyzed redox-neutral annulation proceeds via a condensation/1,5-hydride shift/ring-closure sequence. Polycyclic azepinoindoles and related compounds are obtained in a single step with good to excellent yields.

引用

页码：2100 / 2103

页数：4

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