Targeting the neural cell adhesion molecule in cancer

被引：71
作者：
Jensen, Markus
Berthold, Frank
机构：
[1] Univ Cologne, Dept Paediat Oncol & Hematol, D-50924 Cologne, Germany
[2] Univ Cologne, Ctr Mol Med Cologne, Cologne, Germany
来源：
CANCER LETTERS | 2007年 / 258卷 / 01期
关键词：
neural cell adhesion molecule; NCAM; tumour targeting; monoclonal antibodies; immunotherapy;
D O I：
10.1016/j.canlet.2007.09.004
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
NCAM is a tumour associated antigen expressed on small cell lung cancer, neuroblastoma, rhabdomyosarkoma, brain tumours, multiple myelomas and acute myeloid leukaemia. Constant and strong expression of NCAM is a prerequisite for the development of antibody-based immunotherapies. From the spectrum of existing anti-NCAM compounds, radioimmunoconjugates and immunotoxins represent the clinically most advanced and successful strategies. Here we provide an overview of the evolving field of anti-NCAM immunotherapy for cancer and discuss its indications and limitations. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：9 / 21
页数：13
相关论文
共 91 条
[51]   Immunotoxin therapy of small-cell lung cancer: A phase I study of N901-blocked ricin [J].
Lynch, TJ ;
Lambert, JM ;
Coral, F ;
Shefner, J ;
Wen, P ;
Blattler, WA ;
Collinson, AR ;
Ariniello, PD ;
Braman, G ;
Cook, S ;
Esseltine, D ;
Elias, A ;
Skarin, A ;
Ritz, J .
JOURNAL OF CLINICAL ONCOLOGY, 1997, 15 (02) :723-734
[52]   IMMUNOTOXIN THERAPY OF SMALL-CELL LUNG-CANCER - N901-BLOCKED RICIN FOR RELAPSED SMALL-CELL LUNG-CANCER [J].
LYNCH, TJ .
CHEST, 1993, 103 (04) :S436-S439
[53]   Intraperitioneal bispecific antibody (HEA125xOKT3) therapy inhibits malignant ascites production in advanced ovarian carcinoma [J].
Marmé, A ;
Strauss, G ;
Bastert, G ;
Grischke, EM ;
Moldenhauer, G .
INTERNATIONAL JOURNAL OF CANCER, 2002, 101 (02) :183-189
[54]  
MECHTERSHEIMER G, 1991, CANCER RES, V51, P1300
[55]   INTERACTIONS OF THE CHONDROITIN SULFATE PROTEOGLYCAN PHOSPHACAN, THE EXTRACELLULAR DOMAIN OF A RECEPTOR-TYPE PROTEIN-TYROSINE-PHOSPHATASE, WITH NEURONS, GLIA, AND NEURAL CELL-ADHESION MOLECULES [J].
MILEV, P ;
FRIEDLANDER, DR ;
SAKURAI, T ;
KARTHIKEYAN, L ;
FLAD, M ;
MARGOLIS, RK ;
GRUMET, M ;
MARGOLIS, RU .
JOURNAL OF CELL BIOLOGY, 1994, 127 (06) :1703-1715
[56]   Neural cell adhesion molecule is endocytosed via a clathrin-dependent pathway [J].
Miñana, R ;
Duran, JM ;
Tomas, M ;
Renau-Piqueras, J ;
Guerri, C .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2001, 13 (04) :749-756
[57]  
Miotti S, 1999, INT J CANCER, V84, P62, DOI 10.1002/(SICI)1097-0215(19990219)84:1<62::AID-IJC12>3.3.CO
[58]  
2-K
[59]   Expression of neural cell adhesion molecules and neurofilament protein isoforms in skeletal muscle tumors [J].
Molenaar, WM ;
Muntinghe, FLH .
HUMAN PATHOLOGY, 1998, 29 (11) :1290-1293
[60]   Cancer regression in patients after transfer of genetically engineered lymphocytes [J].
Morgan, Richard A. ;
Dudley, Mark E. ;
Wunderlich, John R. ;
Hughes, Marybeth S. ;
Yang, James C. ;
Sherry, Richard M. ;
Royal, Richard E. ;
Topalian, Suzanne L. ;
Kammula, Udai S. ;
Restifo, Nicholas P. ;
Zheng, Zhili ;
Nahvi, Azam ;
de Vries, Christiaan R. ;
Rogers-Freezer, Linda J. ;
Mavroukakis, Sharon A. ;
Rosenberg, Steven A. .
SCIENCE, 2006, 314 (5796) :126-129
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