Targeting the neural cell adhesion molecule in cancer

被引：71
作者：
Jensen, Markus
Berthold, Frank
机构：
[1] Univ Cologne, Dept Paediat Oncol & Hematol, D-50924 Cologne, Germany
[2] Univ Cologne, Ctr Mol Med Cologne, Cologne, Germany
来源：
CANCER LETTERS | 2007年 / 258卷 / 01期
关键词：
neural cell adhesion molecule; NCAM; tumour targeting; monoclonal antibodies; immunotherapy;
D O I：
10.1016/j.canlet.2007.09.004
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
NCAM is a tumour associated antigen expressed on small cell lung cancer, neuroblastoma, rhabdomyosarkoma, brain tumours, multiple myelomas and acute myeloid leukaemia. Constant and strong expression of NCAM is a prerequisite for the development of antibody-based immunotherapies. From the spectrum of existing anti-NCAM compounds, radioimmunoconjugates and immunotoxins represent the clinically most advanced and successful strategies. Here we provide an overview of the evolving field of anti-NCAM immunotherapy for cancer and discuss its indications and limitations. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
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收藏
页码：9 / 21
页数：13
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