Long-Term Outcomes of Patients with Squamous Cell Carcinoma of the Temporal Bone after Concomitant Chemoradiotherapy

被引:13
作者
Shiga, Kiyoto [1 ]
Katagiri, Katsunori [1 ]
Saitoh, Daisuke [1 ]
Ogawa, Takenori [2 ]
Higashi, Kenjiro [2 ]
Ariga, Hisanori [3 ]
机构
[1] Iwate Med Univ, Iwate Med Univ Hosp, Dept Head & Neck Surg, 19-1 Uchimaru, Morioka, Iwate 0208505, Japan
[2] Tohoku Univ, Tohoku Univ Hosp, Dept Otolaryngol Head & Neck Surg, Sendai, Miyagi, Japan
[3] Iwate Med Univ, Iwate Med Univ Hosp, Dept Radiat Oncol, Morioka, Iwate, Japan
关键词
squamous cell carcinoma; external auditory canal; chemoradiotherapy; long-term prognosis; adverse events; complications; RADIATION-THERAPY; NECK-CANCER; CISPLATIN; HEAD; CHEMOTHERAPY; DOCETAXEL; FLUOROURACIL; RESECTION; SURGERY; EAR;
D O I
10.1055/s-0038-1651522
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objectives This article aims to clarify the long-term outcomes of patients with squamous cell carcinoma of the temporal bone who underwent concomitant chemoradiotherapy (CCRT). Design and Setting The study design was a retrospective chart review. Patients and Methods From December 2001 to June 2014, 23 patients with cancer of the temporal bone who were treated by CCRT at the Tohoku University Hospital and the Iwate Medical University Hospital were enrolled in this study. For advanced cancer of the temporal bone, a modified docetaxel, cisplatin, and 5-fluorouracil (TPF) regimen was used for CCRT. The long-term outcomes, including prognoses and late complications, were analyzed after CCRT of patients with cancers of the temporal bone. Results The main long-term complications were stenosis of the external auditory canal and conductive hearing loss. No harmful late complications were observed in these patients. Disease-specific survival rates were 84.9% for all patients, 100% for patients of stage I, II, and III (n=10), and 75.5% for patients of stage IV (n=13) at 5 years. Conclusions Our study showed that CCRT is an effective treatment choice for squamous cell carcinoma of the temporal bone. Furthermore, CCRT using the TPF regimen is a safe and effective initial treatment for patients with advanced cancers of the temporal bone.
引用
收藏
页码:S316 / S321
页数:6
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