Structure and function of mitochondrial supercomplexes

被引：160
作者：
Dudkina, Natalya V. [1 ]
Kouril, Roman [1 ]
Peters, Katrin [2 ]
Braun, Hans-Peter [2 ]
Boekema, Egbert J. [1 ]
机构：
[1] Univ Groningen, Electron Microscopy Grp, Groningen Biomol Sci & Biotechnol Inst, NL-9747 AG Groningen, Netherlands
[2] Leibniz Univ Hannover, Inst Plant Genet, Fac Nat Sci, D-30419 Hannover, Germany
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | 2010年 / 1797卷 / 6-7期
关键词：
Oxidative phosphorylation; Mitochondria; Respirasome; ATP synthase; Electron microscopy; Supercomplex; RESPIRATORY COMPLEX-I; DIMERIC ATP SYNTHASE; CYTOCHROME-C-OXIDASE; 3-DIMENSIONAL STRUCTURE; CHAIN SUPERCOMPLEXES; ORGANIZATION; DOMAIN; YEAST; IDENTIFICATION; CARDIOLIPIN;
D O I：
10.1016/j.bbabio.2009.12.013
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The five complexes (complexes I-V) of the oxidative phosphorylation (OXPHOS) system of mitochondria can be extracted in the form of active supercomplexes. Single-particle electron microscopy has provided 2D and 3D data describing the interaction between complexes I and III, among I. Ill and IV and in a dimeric form of complex V. between two ATP synthase monomers. The stable interactions are called supercomplexes which also form higher-ordered oligomers. Cryo-electron tomography provides new insights on how these supercomplexes are arranged within intact mitochondria. The structure and function of OXPHOS supercomplexes are discussed. (C) 2009 Elsevier B.V. All rights reserved.
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收藏
页码：664 / 670
页数：7
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