T Lymphocytes as Targets for SARS-CoV-2

被引：7

作者：

Kuklina, Elena M. ^{[1
]}

机构：

[1] Russian Acad Sci, Perm Fed Res Ctr, Inst Ecol & Genet Microorganisms, Ural Branch, Perm 614081, Russia

来源：

BIOCHEMISTRY-MOSCOW | 2022年 / 87卷 / 06期

关键词：

SARS-CoV-2; T lymphocytes; ACE2; CD147; Treg; SARS CORONAVIRUS; CD147; INFECTION; RECEPTOR; PROTEIN; ACE2; INVASION; CELLS; GAS6;

D O I：

10.1134/S0006297922060086

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Despite numerous data on the absence or weak expression of the main functional receptor of SARS-CoV-2 angiotensin-converting enzyme 2 (ACE2) by T cells, it was recently demonstrated that the new coronavirus can efficiently infect T lymphocytes. Here, we analyze the data on the alternative (ACE2-independent) pathways of cell infection, identified T cell subpopulations that serve as the most plausible targets of SARS-CoV-2, discuss the mechanisms of virus-cell interaction, including both infectious and non-infectious pathways of T lymphocyte regulation, and estimate the role of the virus-dependent damage of T lymphocytes in COVID-19 pathogenesis. Particular attention is paid to regulatory T cells as potential targets of SARS-CoV-2, as well as to the possible involvement of exosomes in the sensitivity of peripheral T cells to the virus.

引用

页码：566 / 576

页数：11

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