Amount of bone marrow blasts is strongly correlated to NPM1 and FLT3-ITD mutation rate in AML with normal karyotype

被引：12
作者：
Haferlach, Torsten [1 ]
Bacher, Ulrike [2 ]
Alpermann, Tamara [1 ]
Haferlach, Claudia [1 ]
Kern, Wolfgang [1 ]
Schnittger, Susanne [1 ]
机构：
[1] MLL Munich Leukemia Lab, D-81377 Munich, Germany
[2] Univ Canc Ctr Hamburg, Dept Stem Cell Transplantat, Hamburg, Germany
来源：
LEUKEMIA RESEARCH | 2012年 / 36卷 / 01期
关键词：
NPM1; mutation; Founder mutation; FLT3-ITD; Blast percentages; Normal karyotype AML; ACUTE MYELOID-LEUKEMIA; INTERNAL TANDEM DUPLICATION; ACUTE MYELOGENOUS LEUKEMIA; ADULT PATIENTS; GENE-MUTATIONS; PROGNOSTIC-SIGNIFICANCE; UNSELECTED PATIENTS; NUCLEOPHOSMIN; CEBPA; CLASSIFICATION;
D O I：
10.1016/j.leukres.2011.04.026
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
FLT3-ITDs are linked to higher leukocytes/blasts in acute myeloid leukemia. To evaluate the effect of NPM1 mutations, we correlated NPM1mut status with morphology in 805 adult normal karyotype AML. NPM1mut were found in 391/805 (48.6%), FLT3-ITD in 219/805 (27.2%). Frequencies of FLT3-ITD and NPM1mut cases were continuously increasing by blast decades: NPM1mut from 38/123 (30.9%) in 20-29% blast decade to 70/103 (68.0%) in 90-100% decade (p < 0.001), FLT3-ITDs from 15/123 (12.2%) to 58/103 (56.3%) (p < 0.001). Mean WBC count was highest in NPM1-mut/FLT3-ITD-positive and lowest in NPM1-wildtype/FLT3-ITD-negative patients (p < 0.0001); similar for BM blasts. Therefore, FLT3-ITD and NPM1mut might synergistically stimulate blast proliferation. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：51 / 58
页数：8
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