Whole-body 201Tl scintigraphy can detect exercise lower limb perfusion abnormalities in asymptomatic diabetic patients with normal Doppler pressure indices

被引：27

作者：

Duet, M ^{[1
]}

Virally, M ^{[1
]}

Bailliart, O ^{[1
]}

Kevorkian, JP ^{[1
]}

Kedra, AW ^{[1
]}

Benelhadj, S ^{[1
]}

Ajzenberg, C ^{[1
]}

Le Dref, O ^{[1
]}

Guillausseau, PJ ^{[1
]}

机构：

[1] Hop Lariboisiere, Dept Nucl Med, F-75010 Paris, France

来源：

NUCLEAR MEDICINE COMMUNICATIONS | 2001年 / 22卷 / 09期

关键词：

whole-body Tl-201 scintigraphy; exercise; lower limb perfusion; asymptomatic diabetic patients;

D O I：

10.1097/00006231-200109000-00002

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Significant lower limb arterial obstruction is usually detected by Doppler ankle-brachial pressure index (ABPI) measurement. However, ABPI is non-contributory in cases of diabetic medial sclerosis or calcifications and is unsuitable for the detection of small vessel involvement. Thallium-201, a perfusion agent, is frequently used for the investigation of coronary artery disease, and whole-body Tl-201 scintigraphy (WBS) has also been reported to be useful in the assessment of peripheral artery disease (PAD). Thus, we evaluated the clinical feasibility of simultaneous myocardial and lower limb perfusion assessment. WBS was performed after treadmill exercise and myocardial scintigraphy, and again 4 h later. Calf Tl-201 fractional activities (percentage of whole-body Tl-201 uptake) were calculated. We determined a threshold value of normal post-exercise calf Tl-201 uptake (mean of the Tl-201 fractional uptakes minus 2 SD) in a control group of nine healthy volunteers. We checked its accuracy in a pilot group of 25 diabetic patients with proven PAD. This method permitted the detection of lower limb perfusion abnormalities in 38% of 47 asymptomatic diabetic patients with no evidence of PAD. In conclusion, for asymptomatic diabetic patients, whole-body Tl-201 scintigraphy after a treadmill test seems an efficient method of showing lower limb perfusion abnormalities not detected by ABPI measurement. It allows the evaluation of vascular status with no additional inconvenience for patients when performed after myocardial scintigraphy. ((C) 2001 Lippincott Williams & Wilkins).

引用

页码：949 / 954

页数：6

共 21 条

[1]

BOCCALON H, 1995, J MAL VASCUL, V20, P28

[2] The epidemiology and cost of inpatient care for peripheral vascular disease, infection, neuropathy, and ulceration in diabetes [J].