Personalized peptide vaccination for advanced colorectal cancer

被引：7
作者：
Sasada, Tetsuro [1 ,2 ]
Kibe, Shiro [3 ]
Akagi, Yoshito [3 ]
Itoh, Kyogo [1 ]
机构：
[1] Kurume Univ, Canc Vaccine Ctr, Kurume, Fukuoka 830, Japan
[2] Kanagawa Canc Ctr, Res Inst, Canc Vaccine Ctr, Yokohama, Kanagawa 2410815, Japan
[3] Kurume Univ, Dept Surg, Kurume, Fukuoka 830, Japan
来源：
ONCOIMMUNOLOGY | 2015年 / 4卷 / 05期
关键词：
biomarker; colorectal cancer; IL-6; peptide vaccine; personalized vaccine;
D O I：
10.1080/2162402X.2015.1005512
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We have developed a novel approach in cancer immunotherapy, the personalized peptide vaccination (PPV), in which human leukocyte antigen (HLA)-matched peptides are selected on the basis of preexisting host immunity before vaccination. Recently, we demonstrated the feasibility of PPV in previously treated patients with advanced colorectal cancer, thus warranting further clinical development of this approach.
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