Sub-Diffraction Imaging of Huntingtin Protein Aggregates by Fluorescence Blink-Microscopy and Atomic Force Microscopy

被引：38
|
作者：
Duim, Whitney C. [1 ]
Chen, Bryan [2 ]
Frydman, Judith [2 ]
Moerner, W. E. [1 ]
机构：
[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA
[2] Stanford Univ, Dept Biol, Clark Ctr E200, Stanford, CA 94305 USA
来源：
CHEMPHYSCHEM | 2011年 / 12卷 / 13期
基金：
美国国家卫生研究院; 美国国家科学基金会;
关键词：
aggregation; proteins; scanning probe microscopy; single-molecule studies; super-resolution;
D O I：
10.1002/cphc.201100392
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Resolving aggregates: Single-molecule super-resolution imaging of fluorescent Huntington′s disease proteins reveals the detailed morphology of aggregates in aqueous environments (see figure, color) and shows excellent agreement with atomic force microscopy images (figure, black) of the same aggregates. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：2386 / 2389
页数：4
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