Modeling of the Lipid Bilayer Mimicking the Inner Mitochondrial Membrane

被引：0

作者：

Yurchenko, A. A. ^{[1
]}

Korotkova, P. D. ^{[2
]}

Gusel'nikova, A. R. ^{[1
]}

Shumm, A. B. ^{[2
,3
]}

Timofeev, V., I ^{[4
,5
]}

Vladimirov, Yu A. ^{[1
,2
,4
,6
]}

机构：

[1] Pirogov Russian Natl Res Med Univ, Moscow 117997, Russia

[2] Lomonosov Moscow State Univ, Moscow 119991, Russia

[3] Russian Acad Sci, Lebedev Phys Inst, Moscow 119991, Russia

[4] Russian Acad Sci, Shubnikov Inst Crystallog, Fed Sci Res Ctr Crystallog & Photon, Moscow 119333, Russia

[5] Kurchatov Inst, Dept NBICS Nat Technol, Natl Res Ctr, Moscow 123182, Russia

[6] Sechenov First Moscow State Med Univ, Inst Regenerat Med, Moscow 119991, Russia

来源：

CRYSTALLOGRAPHY REPORTS | 2021年 / 66卷 / 06期

基金：

俄罗斯科学基金会;

关键词：

CYTOCHROME-C; MOLECULAR-MECHANISMS; APOPTOSIS; CARDIOLIPIN; ACTIVATION; STRESS; DEATH; CELLS; AMBER; P53;

D O I：

10.1134/S1063774521060432

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

The model of the lipid bilayer mimicking the inner mitochondrial membrane was constructed. Each layer of the lipid bilayer model consists of 51 dilinoleoyl phosphatidylethanolamine molecules, 36 dilinoleoyl phosphatidylcholine molecules, 35 tetraoleoyl cardiolipin molecules, and 6 dilinoleoyl phosphatidylinositol molecules. This model was analyzed by molecular dynamics simulation (20 000 ps). The mobility of different lipids and groups of atoms involved in the lipids is described. This model can be used to study the lipid component of the inner mitochondrial membrane.

引用

页码：1006 / 1009

页数：4

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