Minocycline-induced staining of torus palatinus and alveolar bone

Background: Minocycline hydrochloride, an analog of tetracycline, is widely used in the treatment of acne. Its use has been associated with discoloration of teeth, bone, and other tissues. Methods: A case is presented involving a patient with minocycline-induced staining of the torus palatinus and alveolar bone. Results: No treatment was rendered since the patient was not concerned with the appearance of the discoloration. The patient's dermatologist elected to change antibiotics. Conclusions: Patients on long-term minocycline therapy should be made aware of the possibility of pigmentation of bone and soft tissue that may be reversible with discontinuation of therapy; however, minocycline-induced staining of the permanent dentition may not be reversible.