PINK1/Parkin-mediated mitophagy in cardiovascular disease: From pathogenesis to novel therapy

被引：54

作者：

Wu, Yanze ^{[1
,2
]}

Jiang, Ting ^{[3
]}

Hua, Jinghai ^{[1
]}

Xiong, Zhiping ^{[1
]}

Dai, Kai ^{[1
]}

Chen, Hui ^{[1
]}

Li, Lei ^{[1
]}

Peng, Jingtian ^{[1
]}

Peng, Xiaoping ^{[1
]}

Zheng, Zeqi ^{[1
]}

Xiong, Wenjun ^{[1
]}

机构：

[1] Nanchang Univ, Affiliated Hosp 1, Dept Cardiol, 17 yongwaizheng St, Nanchang 330006, Jiangxi, Peoples R China

[2] Nanchang Univ, Jiangxi Med Coll, Nanchang 330006, Jiangxi, Peoples R China

[3] Nanchang Univ, Dept Hosp Infect Control, Affiliated Hosp 1, Nanchang 330006, Jiangxi, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2022年 / 361卷

关键词：

PINK1; Parkin; Mitophagy; Mitochondria; Cardiovascular disease; Cardiomyocyte; MITOCHONDRIAL DYSFUNCTION; RAT MODEL; REGULATES MITOPHAGY; CARDIAC INJURY; HEART-FAILURE; PARKIN; PINK1; AUTOPHAGY; PTEN; DEFICIENCY;

D O I：

10.1016/j.ijcard.2022.05.025

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cardiovascular disease(CVD)is one of the predominant causes of death and morbidity. Mitochondria play a key role in maintaining cardiac energy metabolism. However, mitochondrial dysfunction leads to excessive production of ROS, resulting in oxidative damage to cardiomyocytes and contributing to a variety of cardiovascular diseases. In such a case, the clearance of impaired mitochondria is necessary. Currently, most studies have indicated an essential role for mitophagy in maintaining cardiac homeostasis and regulating CVD-related metabolic transition. Recent studies have implicated that PTEN-induced putative kinase 1 (PINK1)/Parkinmediated mitophagy has been implicated in maintaining cardiomyocyte homeostasis. Here, we discuss the physiological and pathological roles of PINK1/Parkin-mediated mitophagy in the cardiovascular system, as well as potential therapeutic strategies based on PINK1/Parkin-mediated mitophagy modulation, which are of great significance for the prevention and treatment of cardiovascular diseases.

引用

页码：61 / 69

页数：9

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