Design, synthesis and synergistic antioxidant, antibacterial, antifungal activity of nitrogen heterocycles

被引：0

作者：

Sahu, Pramod Kumar ^{[1
,2
]}

Sahu, Praveen Kumar ^{[2
]}

Agarwal, Dau Dayal ^{[2
]}

机构：

[1] Jiwaji Univ, Sch Studies Chem, Gwalior 474011, Madhya Pradesh, India

[2] Jiwaji Univ, Dept Ind Chem, Gwalior 474011, Madhya Pradesh, India

来源：

JOURNAL OF THE INDIAN CHEMICAL SOCIETY | 2015年 / 92卷 / 02期

关键词：

Antioxidant activity; antimicrobial activity; green synthesis; cytotoxicity; heterocycles; ONE-POT SYNTHESIS; MULTICOMPONENT REACTIONS; CYCLIZATION REACTIONS; DERIVATIVES; 3-COMPONENT; TOXICITY;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A convenient, facile and efficiently catalyzed synthesis of nitrogen heterocycles using aldehydes, 1,3-dicarbonyl and 3-amino-1,2,4-triazole/urea/thiourea/2-amino benzothiazole in the presence of L-proline at 65-70 degrees C under solvent free conditions is being described. Results clearly demonstrated that the effect of these heterocycles have quinazolines. quinazolinones and 4H-pyrimido[2,1-Mbenzothiazole especially para and ortho hydroxyl substituted derivatives being more pronounced for antioxidant activity. Results suggested that derivative 1c, Id, 2b. 3a, 3b and 4 exhibited good inhibitory effect against tested bacterial species and derivatives 1c, 1d and 2b showed the good spectrum for fungal activity.

引用

页码：169 / 182

页数：14

共 45 条

[1] Synthesis and pharmacological investigation of novel 4-benzyl-1-substituted-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-ones as new class of H1-antihistaminic agents [J].

Alagarsamy, V. ;

Solomon, V. R. ;

Murugan, M. .

BIOORGANIC & MEDICINAL CHEMISTRY, 2007, 15 (12) :4009-4015

[2] Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-methyl-3-substituted quinazolin-4-(3H)-ones [J].

Alagarsamy, V ;

Murugananthan, G ;

Venkateshperumal, R .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2003, 26 (12) :1711-1714

[3]

Alagarsamy V., 2007, Indian Journal of Pharmaceutical Sciences, V69, P304

[4] Synthesis and anti-inflammatory activity of some [4,6-(4-substituted aryl)-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl]-acetic acid derivatives [J].

Bahekar, SS ;

Shinde, DB .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (07) :1733-1736

[5] MASTERING BETA-KETO-ESTERS [J].

BENETTI, S ;

ROMAGNOLI, R ;

DERISI, C ;

SPALLUTO, G ;

ZANIRATO, V .

CHEMICAL REVIEWS, 1995, 95 (04) :1065-1114

[6] Asymmetric aldol reactions in poly(ethylene glycol) catalyzed by L-proline [J].

Chandrasekhar, S ;

Narsihmulu, C ;

Reddy, NR ;

Sultana, SS .

TETRAHEDRON LETTERS, 2004, 45 (23) :4581-4582

[7] Zn-proline catalyzed direct aldol reaction in aqueous media [J].

Darbre, T ;

Machuqueiro, M .

CHEMICAL COMMUNICATIONS, 2003, (09) :1090-1091

[8] Recent developments in isocyanide based multicomponent reactions in applied chemistry [J].

Dömling, A .

CHEMICAL REVIEWS, 2006, 106 (01) :17-89

[9]

EI-Gazzar A. R. B. A., 2009, EUR J MED CHEM, V44, P4249

[10] Synthesis and evaluation of the biological activities of some 3-{[5-(6-methyl-4-aryl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-oxadiazol-2-yl]-imino}-1,3-dihydro-2H-indol-2-one derivatives [J].

George, Sonia ;

Parameswaran, Manoj Kumar ;

Chakraborty, Acharjee Raja ;

Ravi, Thengungal Kochupappy .

ACTA PHARMACEUTICA, 2008, 58 (01) :119-129

← 1 2 3 4 5 →