Final step gallium-68 radiolabelling of silica-coated iron oxide nanorods as potential PET/MR multimodal imaging agents

被引：27

作者：

Burke, Benjamin P. ^{[1
,2
]}

Baghdadi, Neazar ^{[1
]}

Clemente, Goncalo S. ^{[2
]}

Camus, Nathalie ^{[3
]}

Guillou, Amaury ^{[3
]}

Kownacka, Alicja E. ^{[1
]}

Domarkas, Juozas ^{[1
,2
]}

Halime, Zakaria ^{[3
]}

Tripier, Raphael ^{[3
]}

Archibald, Stephen J. ^{[1
,2
]}

机构：

[1] Univ Hull, Dept Chem, Kingston Upon Hull HU6 7RX, N Humberside, England

[2] Univ Hull, Positron Emiss Tomog Res Ctr, Kingston Upon Hull HU6 7RX, N Humberside, England

[3] Univ Brest, UMR CNRS SFR148 ScInBioS 6521, UFR Sci & Tech, F-93837 Brest, France

来源：

FARADAY DISCUSSIONS | 2014年 / 175卷

关键词：

POSITRON-EMISSION-TOMOGRAPHY; CU-64-LABELED MAGNETIC NANOPARTICLES; IN-VIVO EVALUATION; BIOMEDICAL APPLICATIONS; CONTRAST AGENTS; MULTIFUNCTIONAL NANOPARTICLES; SURFACE MODIFICATION; INTRACELLULAR UPTAKE; QUANTUM DOTS; MRI;

D O I：

10.1039/c4fd00137k

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The investigation of iron oxide-based positron emission tomography/magnetic resonance (PET/MR) multimodal imaging agents is an expanding field in which a variety of nanoparticle sizes, shapes, surface coatings and radioisotopes are open for exploration. This study develops iron oxide nanorods which are coated with various mixtures of poly(ethylene glycol) (PEG) and macrocyclic ligand (DO3A) via the formation of a silica layer on the surface. Gallium-68 radiolabelling of the nanorods was carried out in high radiochemical yields (RCY) and their stability in human serum was demonstrated for all constructs, even in the absence of the macrocyclic chelating unit. Further studies were carried out in an attempt to determine the appropriate amount of PEG coating to give optimal properties for future in vivo studies.

引用

页码：59 / 71

页数：13

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