Two new antibacterial sesquiterpenoids from Centipeda minima

被引：26

作者：

Liang, Heng-Xing ^{[1
,2
]}

Bao, Fu-Kai ^{[3
]}

Dong, Xiao-Ping ^{[2
]}

Zhu, Hua-Jie ^{[1
]}

Lu, Xiao-Jie ^{[1
]}

Shi, Ming ^{[3
]}

Lu, Qing ^{[1
]}

Cheng, Yong-Xian ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

[2] Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 610075, Peoples R China

[3] Kunming Med Coll, Dept Microbiol & Immunol, Kunming 650031, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2007年 / 4卷 / 12期

关键词：

D O I：

10.1002/cbdv.200790230

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two new guaiane-type sesquiterpene lactones, compounds I and 2, along with three known Guaianolide- or pseudoguaianolides, were isolated from Centipeda minima (whole plant). Their structures were identified by spectroscopic and mass-spectrometric analyses. The configuration at C(5) of the guaiane framework of I was rationalized by quantum-mechanical calculations (Table 2). All compounds were found to be active against eight different microbial pathogens (Table 3), with MIC values in the range of 6.25-100 mu g/ml.

引用

页码：2810 / 2816

页数：7

共 29 条

[1] EVALUATION OF ALAMAR COLORIMETRIC MIC METHOD FOR ANTIMICROBIAL SUSCEPTIBILITY TESTING OF GRAM-NEGATIVE BACTERIA [J].