Parkinsonism-Hyperpyrexia Syndrome: A Case Series and Literature Review

被引：4

作者：

Azar, Jehad ^{[1
]}

Jaber, Yasmin ^{[2
]}

Ayyad, Mohammed ^{[3
]}

Abu Alia, Walaa ^{[4
]}

Owda, Fahed ^{[5
]}

Sharabati, Haneen ^{[3
]}

Zeid, Hiba ^{[6
]}

Khreshi, Suleiman ^{[7
]}

AlBandak, Maram ^{[3
]}

Ahmad, Dana Sayyed ^{[3
]}

机构：

[1] Cleveland Clin, Resp Inst, Cleveland, OH 44106 USA

[2] Georgetown Univ, Med Ctr, Oncol, Washington, DC 20007 USA

[3] Al Quds Univ, Internal Med, Jerusalem, Israel

[4] Cleveland Clin, Fairview Hosp, Internal Med, Cleveland, OH 44106 USA

[5] An Najah Natl Univ, Internal Med, Nablus, Israel

[6] Waterbury Hosp & Hlth Ctr, Internal Med, Waterbury, CT USA

[7] St Mary Hosp, Internal Med, Langhorne, PA USA

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2022年 / 14卷 / 09期

关键词：

neuroleptic malignant syndrome; levodopa-carbidopa; dopaminergic withdrawal; deep brain stimulator; parkinsonism-hyperpyrexia syndrome; parkinson's disease (pd); DEEP BRAIN-STIMULATION; NEUROLEPTIC MALIGNANT SYNDROME; SUBTHALAMIC NUCLEUS; WITHDRAWAL SYNDROME; DISEASE; PATIENT; SEPSIS;

D O I：

10.7759/cureus.29646

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Parkinsonism-hyperpyrexia syndrome (PHS) is a rare, potentially fatal neurological emergency, that is seen in Parkinson's Disease (PD) patients and mimics neuroleptic malignant syndrome. The most common trigger for PHS is sudden withdrawal of anti-parkinsonian medications, specifically levodopa. However, it can also be due to Deep Brain Stimulation (DBS) device malfunction. In this work, we describe three cases of PHS; the first of which is related to DBS battery depletion, and the remaining two to dopaminergic withdrawal. Additionally, we will include the results of a literature review on PHS, its etiologies, presentation, and management.

引用

页数：10

共 30 条

[1] Life-threatening parkinsonism-hyperpyrexia syndrome following bilateral deep brain stimulation of the subthalamic nucleus [J].