Outcome of urinary tract infection caused by Extended Spectrum Beta-Lactamase (ESBL) producing Escherichia coli and Klebsiella pneumoniae in Dr Zainoel Abidin General Hospital Aceh

被引:6
作者
Hayati, Zinatul [1 ]
Jamil, Kurnia F. [2 ]
Azhari, Afrianda [3 ]
Mahdani, Wilda [1 ]
Karmil, Teuku Fadrial [4 ]
Yossadania, Asyriva [5 ]
Dahril [6 ]
Habibie, Yopie Afriandi [7 ]
机构
[1] Univ Syiah Kuala, Fac Med, Dept Microbiol, Dr Zainoel Abidin Gen Hosp, Banda Aceh 23126, Indonesia
[2] Univ Syiah Kuala, Fac Med, Dept Internal Med, Dr Zainoel Abidin Gen Hosp, Banda Aceh 23126, Indonesia
[3] Univ Syiah Kuala, Fac Med, Banda Aceh 23111, Indonesia
[4] Univ Syiah Kuala, Fac Vet Med, Dept Clin Vet, Banda Aceh 23111, Indonesia
[5] Univ Syiah Kuala, Fac Med, Dept Publ Hlth, Banda Aceh 23111, Indonesia
[6] Univ Syiah Kuala, Fac Med, Dept Urol, Dr Zainoel Abidin Hosp, Banda Aceh 23126, Indonesia
[7] Univ Syiah Kuala, Fac Med, Dr Zainoel Abidin Gen Hosp, Div Thorac Cardiac & Vasc Surg,Dept Surg, Banda Aceh 23126, Indonesia
关键词
Ceftriaxone; ESBL; Escherichia coli; Klebsiella pneumoniae; UTI;
D O I
10.15562/bmj.v10i2.2385
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction: Extended-spectrum beta-lactamase (ESBL) is a mutated beta-lactamase enzyme that can hydrolyze beta-lactam antibiotics. The aim of this study was to determine the incidence rate, characteristics of patients, antibiotic use and outcome of urinary tract infections (UTIs) due to ESBL-producing Escherichia coli and Klebsiella pneumoniae at Dr Zainoel Abidin General Hospital Aceh. Method: The samples of this study were all Escherichia coli and Klebsiella pneumoniae isolated from urine culture of UTI cases. Patient characteristics and antibiotic use data were extracted from medical records. UTIs outcome was assessed as clinical improvement or death within a maximum of 30 days of treatment. Result: The results of this study obtained 63 patients with UTIs caused by E. coli and K. pneumonia of which 52.4% of them were ESBL producers. The incidence of UTIs due to E. coli was higher than that of K. pneumoniae, 63.5% and 36.5% respectively. E. coli ESBL producers were more in number than non-ESBL, conversely K. pneumoniae were mostly non-ESBL. The characteristics of patients with UTIs caused by E. coli and K. pneumoniae were predominant women 52.4%, and most cases were at 56-64 years old. Antibiotic therapy that given before and after culture results to UTI patients were generally ceftriaxone. UTIs outcome due to ESBL producing Escherichia coli and Klebsiella pneumoniae showed that 26/33 (78.8%) patients experienced improvement, however, 7/33 (21.2%) patients died. Conclusion: The irrational use of ceftriaxone in patients with UTI caused by ESBL producing E. coli and K. pneumoniae has led to a poor outcome for the patient.
引用
收藏
页码:544 / 548
页数:5
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