Lipase-mediated multicomponent synthesis of 1H-Pyrazolo[1,2-b]phthalazine-5,10-dione derivatives in a binary solvent medium

被引：4

作者：

Dalal, Kiran S. ^{[1
]}

Tayade, Yogesh A. ^{[2
]}

Wagh, Yogesh B. ^{[3
]}

Dalal, Dipak S. ^{[3
]}

Chaudhari, Bhushan L. ^{[1
]}

机构：

[1] Kavayitri Bahinabai Chaudhari North Maharashtra U, Sch Life Sci, Jalgaon 425001, Maharashtra, India

[2] Dhanaji Nana Mahavidyalaya, Jalgaon, Maharashtra, India

[3] Kavayitri Bahinabai Chaudhari North Maharashtra U, Sch Chem Sci, Jalgaon, Maharashtra, India

来源：

BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY | 2022年 / 69卷 / 05期

关键词：

1H-pyrazolo[1; 2-b]phthalazine-5; 10-dione; Aspergillus niger; lipase; ONE-POT SYNTHESIS; EFFICIENT SYNTHESIS; ASPERGILLUS; PHOSPHODIESTERASE; NANOPARTICLES; OPTIMIZATION; PHTHALAZINES; RESOLUTION; CARBONATE; CATALYST;

D O I：

10.1002/bab.2264

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new method for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives via lipase from the Aspergillus niger-catalyzed multicomponent reaction of aldehydes, malononitrile, and phthalhydrazide is reported herein for the first time. This novel method holds several advantages, including its efficiency, environmental friendliness, simple workup procedure, and good yield (70-86%). The effects of temperature, organic solvents, and water content were investigated. This protocol has the potential to replace traditional chemical synthesis routes for the synthesis of nitrogen-containing heterocyclic compounds.

引用

页码：2017 / 2027

页数：11

共 55 条

[1]

Al'-Assar F., 2002, PHARM CHEM J+, V36, P598

[2]

Badhe K., 2018, DER PHARM CHEM, V10, P135

[3] Multicomponent synthesis of dihydropyrano[2,3-c]pyrazoles catalyzed by lipase from Aspergillus niger [J].

Bora, Pranjal P. ;

Bihani, Manisha ;

Bez, Ghanashyam .

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 2013, 92 :24-33

[4]

Chaskar, 2014, CURR CATAL, V3, P266, DOI [10.2174/2211544703666140417230832, DOI 10.2174/2211544703666140417230832]

[5] Industrial applications of enzyme biocatalysis: Current status and future aspects [J].

Choi, Jung-Min ;

Han, Sang-Soo ;

Kim, Hak-Sung .

BIOTECHNOLOGY ADVANCES, 2015, 33 (07) :1443-1454

[6] Multicomponent reactions: advanced tools for sustainable organic synthesis [J].

Cioc, Razvan C. ;

Ruijter, Eelco ;

Orru, Romano V. A. .

GREEN CHEMISTRY, 2014, 16 (06) :2958-2975

[7] Esterification of (RS)-ibuprofen by native and commercial lipases in a two-phase system containing ionic liquids [J].

Contesini, Fabiano Jares ;

Carvalho, Patricia de Oliveira .

TETRAHEDRON-ASYMMETRY, 2006, 17 (14) :2069-2073

[8] Hen Egg White Lysozyme Catalyzed Efficient Synthesis of 3-Indolyl-3-hydroxy Oxindole in Aqueous Ethanol [J].

Dalal, Kiran S. ;

Wagh, Yogesh B. ;

Tayade, Yogesh A. ;

Dalal, Dipak S. ;

Chaudhari, Bhushan L. .

CATALYSIS LETTERS, 2018, 148 (11) :3335-3341

[9] Lipase from Porcine Pancreas: An Efficient Biocatalyst for the Synthesis of ortho-Aminocarbonitriles [J].

Dalal, Kiran S. ;

Padvi, Swapnil A. ;

Wagh, Yogesh B. ;

Dalal, Dipak S. ;

Chaudhari, Bhushan L. .

CHEMISTRYSELECT, 2018, 3 (37) :10378-10382

[10] Optimization of enantioselective resolution of racemic ibuprofen by native lipase from Aspergillus niger [J].

de O. Carvalho, Patricia ;

Contesini, Fabiano J. ;

Bizaco, Renato ;

Calafatti, Silvana Ap. ;

Macedo, Gabriela A. .

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, 2006, 33 (08) :713-718

← 1 2 3 4 5 6 →