Medicinal Flowers. XXXI. Acylated Oleanane-Type Triterpene Saponins, Sasanquasaponins I-V, with Antiallergic Activity from the Flower Buds of Camellia sasanqua

被引：43

作者：

Matsuda, Hisashi ^{[1
]}

Nakamura, Seikou ^{[1
]}

Fujimoto, Katsuyoshi ^{[1
]}

Moriuchi, Ryo ^{[1
]}

Kimura, Yuta ^{[1
]}

Ikoma, Noriko ^{[1
]}

Hata, Yuki ^{[1
]}

Muraoka, Osamu ^{[2
]}

Yoshikawa, Masayuki ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, Yamashina Ku, Kyoto 6078412, Japan

[2] Kinki Univ, Pharmaceut Res & Technol Inst, Osaka 5778502, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2010年 / 58卷 / 12期

关键词：

Camellia sasanqua; sasanquasaponin; medicinal flower; antiallergic activity; degranulation inhibitor; rat basophile leukemia 2H3 cell; CHINESE NATURAL MEDICINES; HISTAMINE-RELEASE INHIBITORS; RBL-2H3; CELLS; BIOACTIVE CONSTITUENTS; STRUCTURAL REQUIREMENTS; STELLARIA-DICHOTOMA; PANCREATIC LIPASE; NOROLEANANE-TYPE; TEA FLOWER; TNF-ALPHA;

D O I：

10.1248/cpb.58.1617

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The methanolic extract and its 1-butanol-soluble fraction from the flower buds of Camellia sasanqua THUNB. were found to show inhibitory activities on the release of beta-hexosaminidase from rat basophile leukemia (RBL-2H3) cells. From the 1-butanol-soluble fraction, five new acylated oleanane-type triterpene saponins, sasanquasaponms I-V, were isolated together with a known saponin and their chemical structures were elucidated on the basis of chemical and physicochemical evidence. The principal saponin constituents, sasanquasaponins I-III with an acyl group at the 22-position of the aglycon part showed the inhibitory effects on the release of beta-hexosaminidase and some structure activity relationships were reported.

引用

页码：1617 / 1621

页数：5

共 33 条

[1] ADENINE METABOLISM AND THE SYNTHESIS OF PURINE ALKALOIDS IN FLOWERS OF CAMELLIA [J].