Arsenic trioxide promotes senescence and regulates the balance of adipogenic and osteogenic differentiation in human mesenchymal stem cells

被引：36

作者：

Cheng, Huanchen ^{[1
,2
]}

Qiu, Lin ^{[2
]}

Zhang, Hao ^{[2
]}

Cheng, Mei ^{[2
]}

Li, Wei ^{[2
]}

Zhao, Xuefei ^{[2
]}

Liu, Keyu ^{[2
]}

Lei, Lei ^{[1
]}

Ma, Jun ^{[2
]}

机构：

[1] Harbin Med Univ, Dept Histol & Embryol, Harbin 150081, Peoples R China

[2] Harbin First Hosp, Inst Harbin Hematol & Oncol, Harbin 150010, Peoples R China

来源：

ACTA BIOCHIMICA ET BIOPHYSICA SINICA | 2011年 / 43卷 / 03期

关键词：

arsenic trioxide; mesenchymal stem cells; differentiation; C/EBP alpha; PPAR gamma; BONE-MARROW; TRABECULAR BONE; OSTEOBLASTOGENESIS; APOPTOSIS; ALPHA;

D O I：

10.1093/abbs/gmq130

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Arsenic trioxide (ATO) as an anti-tumor drug could induce differentiation and apoptosis in tumor cells. Mesenchymal stem cells (MSCs) play important roles in the hematogenesis of bone marrow. Many reports have shown that the disorder of MSC adipogenic and osteogenic differentiation occurs in some diseases. However, reports about the effects of ATO on MSCs are limited. In this study, we found that 1 mu M ATO promoted MSC senescence mainly through p21, although it had no effect on apoptosis at this dose. Furthermore, ATO promoted adipogenic differentiation, but inhibited osteogenic differentiation in MSCs. Our study also showed that CCAAT/enhancer-binding protein alpha C/EBP alpha and peroxisome proliferator-activated receptor gamma PPAR gamma might be involved in the regulation of adipogenic and osteogenic differentiation induced by ATO. Our results indicated that ATO may exert an anti-tumor effect by influencing bone marrow micro-environment. Moreover, it may regulate the adipogenic and osteogenic differentiation of MSCs.

引用

页码：204 / 209

页数：6

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