An improved procedure for the synthesis of benzimidazoles, using palladium-catalyzed aryl-amination chemistry

被引：147

作者：

Brain, CT ^{[1
]}

Steer, JT ^{[1
]}

机构：

[1] Novartis Inst Med Sci, London WC1E 6BS, England

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 17期

关键词：

D O I：

10.1021/jo034824l

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New, improved conditions have been developed and optimized for the synthesis of benzimidazoles by intramolecular palladium-catalyzed aryl-amination chemistry. This methodology, combined with a "catch and release" purification strategy, has led to a range of these heterocycles being prepared rapidly and in excellent yield.

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页码：6814 / 6816

页数：3

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