We report magnetoresistivity measurements on a La1.2Sr1.8Mn2O7 single crystal. The charge transport in the ferromagnetic phase is dominated by two-magnon scattering in the high T range and by weak localization effects at lower T, in the non-metallic regime. In the paramagnetic phase, rho(ab)(T) obeys the adiabatic small polaron hopping mechanism, while rho(c)(T) follows an Arrhenius behavior with the same activation energy. (C) 2003 Elsevier Science B.V. All rights reserved.