Expression of lipoprotein receptors in atherosclerotic lesions

被引：47
作者：
Hiltunen, TP
Ylä-Herttuala, S [1 ]
机构：
[1] Univ Kuopio, AI Virtanen Inst, FIN-70210 Kuopio, Finland
[2] Tampere Univ, Sch Med, Dept Clin Chem, FIN-33101 Tampere, Finland
[3] Tampere Univ Hosp, Tampere, Finland
[4] Univ Kuopio, Dept Med, FIN-70210 Kuopio, Finland
[5] Tampere Univ, Sch Med, Dept Biochem Med, FIN-33101 Tampere, Finland
来源：
ATHEROSCLEROSIS | 1998年 / 137卷
关键词：
scavenger receptor(s); LDL receptor; VLDL receptor; low-density lipoprotein receptor-related protein; apo E; lipoprotein lipase; oxidized LDL; cytokines; regulation;
D O I：
10.1016/S0021-9150(97)00307-9
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Atherosclerosis is characterized by the presence of lipid-loaded cells which are derived from macrophages and smooth muscle cells. Several lipoprotein receptors may be involved in cellular lipid uptake. These receptors include: scavenger receptor(s); LDL receptor-related protein/alpha 2-macroglobulin receptor (LRP); LDL receptor; and VLDL receptor. With the exception of the LDL receptor, all of these receptors are expressed in atherosclerotic lesions. While scavenger receptors are mostly expressed in macrophages, the LRP and VLDL receptor may play an important role in mediating lipid uptake in smooth muscle cells. It is evident that no single receptor pathway is solely responsible for the increased lipid uptake in lesion cells but several redundant mechanisms may contribute to the uptake and degradation of lipoproteins in atherosclerotic lesions. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：S81 / S88
页数：8
相关论文
共 88 条
[1]   Identification of scavenger receptor SR-BI as a high density lipoprotein receptor [J].
Acton, S ;
Rigotti, A ;
Landschulz, KT ;
Xu, SZ ;
Hobbs, HH ;
Krieger, M .
SCIENCE, 1996, 271 (5248) :518-520
[2]  
ACTON SL, 1994, J BIOL CHEM, V269, P21003
[3]   Synthesis, processing, and intracellular transport of CD36 during monocytic differentiation [J].
Alessio, M ;
DeMonte, L ;
Scirea, A ;
Gruarin, P ;
Tandon, NN ;
Sitia, R .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (03) :1770-1775
[4]   The atherogenic lipoprotein Lp(a) is internalized and degraded in a process mediated by the VLDL receptor [J].
Argraves, KM ;
Kozarsky, KF ;
Fallon, JT ;
Harpel, PC ;
Strickland, DK .
JOURNAL OF CLINICAL INVESTIGATION, 1997, 100 (09) :2170-2181
[5]   Oxidation of low density lipoproteins greatly enhances their association with lipoprotein lipase anchored to endothelial cell matrix [J].
Auerbach, BJ ;
Bisgaier, CL ;
Wolle, J ;
Saxena, U .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (03) :1329-1335
[6]   PLATELET SECRETORY PRODUCTS ENHANCE LDL RECEPTOR ACTIVITY AND INHIBIT SCAVENGER RECEPTOR ACTIVITY IN HUMAN MONOCYTE DERIVED MACROPHAGES [J].
AVIRAM, M .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1989, 38 (05) :425-430
[7]   MOUSE MACROPHAGES SYNTHESIZE AND SECRETE A PROTEIN RESEMBLING APOLIPOPROTEIN-E [J].
BASU, SK ;
BROWN, MS ;
HO, YK ;
HAVEL, RJ ;
GOLDSTEIN, JL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (12) :7545-7549
[8]  
BATTEY FD, 1994, J BIOL CHEM, V269, P23268
[9]   THE LDL RECEPTOR RELATED PROTEIN, LRP, IS AN APOLIPOPROTEIN-E-BINDING PROTEIN [J].
BEISIEGEL, U ;
WEBER, W ;
IHRKE, G ;
HERZ, J ;
STANLEY, KK .
NATURE, 1989, 341 (6238) :162-164
[10]   LIPOPROTEIN-LIPASE ENHANCES THE BINDING OF CHYLOMICRONS TO LOW-DENSITY-LIPOPROTEIN RECEPTOR-RELATED PROTEIN [J].
BEISIEGEL, U ;
WEBER, W ;
BENGTSSONOLIVECRONA, G .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (19) :8342-8346
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