Unexpected stereoselective sodium acetate catalyzed multicomponent cyclization of aryl aldehydes, malononitrile and acetone into cis-4-dicyanomethylene-2,6-diarylcyclohexane-1,1-dicarbonitriles

被引：34
作者：
Elinson, Michall N.
Vereshchagin, Anatolii N.
Feducovich, Sergey K.
Zaimovskaya, Tatyana A.
Starikova, Zoya A.
Belyakov, Pavel A.
Nikishin, Gennady I.
机构：
[1] ND Zelinskii Inst Organ Chem, Moscow 119991, Russia
[2] AV Topchiev Petrochem Synth Inst, Moscow 119991, Russia
[3] AN Nesmeyanov Organoelement Cpds Inst, Moscow 119991, Russia
来源：
TETRAHEDRON LETTERS | 2007年 / 48卷 / 38期
基金：
俄罗斯基础研究基金会;
关键词：
multicomponent reaction; stereoselectivity; catalysis; aryl aldehydes; malononitrile; acetone; sodium acetate; 2,6-diarylcyclohexane-1,1-dicarbonitriles;
D O I：
10.1016/j.tetlet.2007.07.119
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new type of multicomponent reaction is described in which five organic molecules form a cyclohexane ring. Aryl aldehydes, malononitrile and acetone in the presence of a catalytic amount of sodium acetate are stereo selectively cyclized into cis-4dicyanomethylene-2,6-diarylcyclohexane-1,1-dicarbonitriles in 30-60% yields. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6614 / 6619
页数：6
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