Molecular Memory of Morphologies by Septins during Neuron Generation Allows Early Polarity Inheritance

被引：21

作者：

Boubakar, Leila ^{[1
]}

Falk, Julien ^{[1
]}

Ducuing, Hugo ^{[1
]}

Thoinet, Karine ^{[1
]}

Reynaud, Florie ^{[1
]}

Derrington, Edmund ^{[1
]}

Castellani, Valerie ^{[1
]}

机构：

[1] Univ Lyon 1 Claude Bernard Lyon 1, CNRS, UMR 5310, NeuroMyoGene Inst,INSERM,U 1217, 16 Rue Raphael Dubois, F-69000 Lyon, France

来源：

NEURON | 2017年 / 95卷 / 04期

基金：

欧洲研究理事会;

关键词：

DORSAL-ROOT GANGLIA; DETAILED NEURITE MORPHOLOGIES; BUD-SITE SELECTION; BUDDING YEAST; CELL POLARITY; IN-VIVO; CYTOKINESIS; EXPRESSION; ASYMMETRY; DIFFERENTIATION;

D O I：

10.1016/j.neuron.2017.07.027

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Transmission of polarity established early during cell lineage history is emerging as a key process guiding cell differentiation. Highly polarized neurons provide a fascinating model to study inheritance of polarity over cell generations and across morphological transitions. Neural crest cells (NCCs) migrate to the dorsal root ganglia to generate neurons directly or after cell divisions in situ. Using live imaging of vertebrate embryo slices, we found that bipolar NCC progenitors lose their polarity, retracting their processes to round for division, but generate neurons with bipolar morphology by emitting processes from the same locations as the progenitor. Monitoring the dynamics of Septins, which play key roles in yeast polarity, indicates that Septin 7 tags process sites for re-initiation of process growth following mitosis. Interfering with Septins blocks this mechanism. Thus, Septins store polarity features during mitotic rounding so that daughters can reconstitute the initial progenitor polarity.

引用

页码：834 / +

页数：23

共 68 条

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