Asymmetric cyclopropane synthesis via phosphine oxide mediated cascade reactions

被引：27

作者：

Boesen, T ^{[1
]}

Fox, DJ ^{[1
]}

Galloway, W ^{[1
]}

Pedersen, DS ^{[1
]}

Tyzack, CR ^{[1
]}

Warren, S ^{[1
]}

机构：

[1] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2005年 / 3卷 / 04期

关键词：

D O I：

10.1039/b413500h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A silyloxy-THF has been converted into a cyclopropane containing three stereocentres as mixture of diastereoisomers. The mechanism of the reaction has been established and the source of stereochemical leakage proposed. An alternative stereospecific cascade reaction has been discovered.

引用

收藏

页码：630 / 637

页数：8

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