Target-Cell-Specific Delivery, Imaging, and Detection of Intracellular MicroRNA with a Multifunctional SnO2 Nanoprobe

被引：112

作者：

Dong, Haifeng ^{[1
]}

Lei, Jianping ^{[1
]}

Ju, Huangxian ^{[1
]}

Zhi, Feng ^{[2
]}

Wang, Hua ^{[3
]}

Guo, Wenjie ^{[2
]}

Zhu, Zhu ^{[1
]}

Yan, Feng ^{[4
]}

机构：

[1] Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Analyt Chem Life Sci, Nanjing 210093, Peoples R China

[2] Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Peoples R China

[3] Beijing Univ Aeronaut & Astronaut, Sch Chem & Environm, Beijing 100191, Peoples R China

[4] Jiangsu Inst Canc Prevent & Cure, Nanjing 210009, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 19期

基金：

中国国家自然科学基金;

关键词：

gene vector; imaging; microRNA detection; multifunctional nanoprobe; SnO2; nanoparticles; CARBON NANOTUBES; NONVIRAL VECTOR; DRUG-DELIVERY; GENE DELIVERY; NANO DEVICE; IN-VIVO; DNA; EXPRESSION; RNAS; POLYETHYLENIMINE;

D O I：

10.1002/anie.201108302

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Right on target: A multifunctional nanoprobe is designed for target-cell-specific imaging and in situ detection of intracellular miRNA. The nanoprobe is prepared by functionalizing SnO 2 nanoparticles with both folic acid (FA), a target-cell-specific moiety to recognize folate receptors overexpressed on cancer cells, and a gene probe to inhibit or recognize intracellular miRNA levels (see scheme). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：4607 / 4612

页数：6

共 56 条

[1] The functions of animal microRNAs [J].

Ambros, V .

NATURE, 2004, 431 (7006) :350-355

[2]

[Anonymous], 2007, ANGEW CHEM

[3] Design of environment-sensitive supramolecular assemblies for intracellular drug delivery: Polymeric micelles that are responsive to intracellular pH change [J].

Bae, Y ;

Fukushima, S ;

Harada, A ;

Kataoka, K .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (38) :4640-4643

[4] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

[5] Folate-receptor-mediated delivery of InP quantum dots for bioimaging using confocal and two-photon microscopy [J].

Bharali, DJ ;

Lucey, DW ;

Jayakumar, H ;

Pudavar, HE ;

Prasad, PN .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (32) :11364-11371

[6] A VERSATILE VECTOR FOR GENE AND OLIGONUCLEOTIDE TRANSFER INTO CELLS IN CULTURE AND IN-VIVO - POLYETHYLENIMINE [J].

BOUSSIF, O ;

LEZOUALCH, F ;

ZANTA, MA ;

MERGNY, MD ;

SCHERMAN, D ;

DEMENEIX, B ;

BEHR, JP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (16) :7297-7301

[7] bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila [J].

Brennecke, J ;

Hipfner, DR ;

Stark, A ;

Russell, RB ;

Cohen, SM .

CELL, 2003, 113 (01) :25-36

[8] Highly efficient molecular delivery into mammalian cells using carbon nanotube spearing [J].

Cai, D ;

Mataraza, JM ;

Qin, ZH ;

Huang, ZP ;

Huang, JY ;

Chiles, TC ;

Carnahan, D ;

Kempa, K ;

Ren, ZF .

NATURE METHODS, 2005, 2 (06) :449-454

[9] MicroRNA signatures in human cancers [J].

Calin, George A. ;

Croce, Carlo M. .

NATURE REVIEWS CANCER, 2006, 6 (11) :857-866

[10] MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells [J].

Chan, JA ;

Krichevsky, AM ;

Kosik, KS .

CANCER RESEARCH, 2005, 65 (14) :6029-6033

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