Chlorin-PEI-labeled cellulose nanocrystals: Synthesis, characterization and potential application in PDT

被引：49

作者：

Drogat, Nicolas ^{[1
]}

Granet, Robert ^{[1
]}

Le Morvan, Caroline ^{[1
]}

Begaud-Grimaud, Gaelle ^{[1
]}

Krausz, Pierre ^{[1
]}

Sol, Vincent ^{[1
]}

机构：

[1] Univ Limoges, Lab Chim Subst Nat, F-87060 Limoges, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 11期

关键词：

Nanoparticles; Cellulose nanocrystals; Photosensitizers; Chlorins; Photodynamic therapy; Vectorization; PHOTODYNAMIC THERAPY; BIOLOGICAL EVALUATION; EFFICIENT ROUTE; DRUG-DELIVERY; PORPHYRIN; PHOTOSENSITIZERS; CANCER;

D O I：

10.1016/j.bmcl.2012.04.044

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This Letter reports the synthesis and characterization of a new series of water-stable and soluble photosensitizers (PS-CNCs) composed of cellulose nanocrystals (CNCs) bearing polyaminated chlorin p6. With a view to improve cancer cell targeting, these photosensitizers were assayed for their antitumor activity against HaCat cell line. IC50 values fell within the nanomolar-range, making these photosensitizers promising for further in vitro and in vivo investigations. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：3648 / 3652

页数：5

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