Vaccination in early life: standing up to the challenges

被引：59

作者：

Mohr, Elodie

Siegrist, Claire-Anne ^{[1
]}

机构：

[1] Univ Geneva, WHO Collaborat Ctr Vaccine Immunol, Dept Pathol Immunol, CH-1211 Geneva 4, Switzerland

来源：

CURRENT OPINION IN IMMUNOLOGY | 2016年 / 41卷

基金：

新加坡国家研究基金会;

关键词：

TOLL-LIKE RECEPTOR; CD4(+) T-CELLS; RECENT THYMIC EMIGRANTS; INFLUENZA VACCINE; DENDRITIC CELLS; IMMUNE-RESPONSES; NLRP3; ACTIVATION; INNATE IMMUNITY; HELPER-CELLS; ADJUVANT;

D O I：

10.1016/j.coi.2016.04.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The challenge for any vaccine design is to elicit protective humoral and/or cytotoxic immunity against life threatening pathogens while remaining innocuous. Neonatal vaccinology faces additional challenges linked to intrinsic peculiarities of the innate and adaptive neonatal immune system. These include anti-inflammatory rather than pro-inflammatory responses to innate signals, preferential Th2 differentiation limiting the induction of Th1 and cytotoxic responses, trends to immunoregulatory responses and weak plasma cell and germinal centre B cell responses. Recent progresses in our understanding of the molecular bases of these physiological peculiarities and of the mode of action of novel adjuvants open new opportunities to design vaccine formulations and immunization strategies better adapted to the early life period.

引用

页码：1 / 8

页数：8

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