The Critical Role of Organic Chemistry in Drug Discovery

被引：26

作者：

Rotella, David P. ^{[1
]}

机构：

[1] Montclair State Univ, Dept Chem & Biochem, Sokol Inst Pharmaceut Life Sci, Chem & Biochem, Montclair, NJ 07043 USA

来源：

ACS CHEMICAL NEUROSCIENCE | 2016年 / 7卷 / 10期

关键词：

AZT; small molecules; drug discovery; organic chemistry;

D O I：

10.1021/acschemneuro.6b00280

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Small molecules remain the backbone for modern drug discovery. They are conceived and synthesized by medicinal chemists, many of whom were originally trained as organic chemists. Support from government and industry to provide training and personnel for continued development of this critical skill set has been declining for many years. This Viewpoint highlights the value of organic chemistry and organic medicinal chemists in the complex journey of drug discovery as a reminder that basic science support must be restored.

引用

页码：1315 / 1316

页数：2