Splenomegaly and modified erythropoiesis in KLF13-/- mice

被引：34

作者：

Gordon, Adele R. ^{[2
]}

Outram, Susan V. ^{[3
]}

Keramatipour, Mohammad ^{[2
]}

Goddard, Catherine A. ^{[2
]}

Colledge, William H. ^{[4
]}

Metcalfe, James C. ^{[2
]}

Hager-Theodorides, Ariadne L. ^{[3
]}

Crompton, Tessa ^{[3
]}

Kemp, Paul R. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London SW7 2AZ, England

[2] Univ Cambridge, Dept Biochem, Sect Cardiovasc Biol, Cambridge CB2 1QW, England

[3] Univ London Imperial Coll Sci Technol & Med, Div Cell & Mol Biol, London SW7 2AZ, England

[4] Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge CB2 3EG, England

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2008年 / 283卷 / 18期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1074/jbc.M709569200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To study the function of the Kruppel-like transcription factor KLF13 in vivo, we generated mice with a disrupted Klf13 allele. Although Klf13(-/-) mice are viable, fewer mice were present at 3 weeks than predicted by Mendelian inheritance. Viable Klf13(-/-) mice had reduced numbers of circulating erythrocytes and a larger spleen. The spleen contained an increased number of Ter119(med)CD71(hi), Ter119(hi)CD71(hi), and Ter119(hi)CD71(med) cells but not Ter119(hi)CD71(-) cells, indicating an increase in less mature erythroblasts. A higher proportion of the Ter119(med)CD71(hi) cells were proliferating, indicating that the mice were under a degree of erythropoietic stress. These data indicate that KLF13 is involved in the normal control of erythropoiesis.

引用

页码：11897 / 11904

页数：8

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