RETRACTED: Bachu Mushroom Polysaccharide Alleviates Colonic Injury by Modulating the Gut Microbiota (Retracted Article)

被引：8

作者：

Abdureyim, Zumrat ^{[1
]}

Wang, Lei ^{[2
,3
]}

Tao, Qing ^{[2
]}

Xu, Jing ^{[2
]}

Yimiti, Delixiati ^{[1
]}

Gao, Qian ^{[2
]}

机构：

[1] Xinjiang Med Univ, Coll Publ Hlth, Dept Labor Hyg & Environm Hyg, Xinjiang 830017, Peoples R China

[2] Nanjing Univ, Sch Med, Key Labs Mol Med Jiangsu Prov, Nanjing 210003, Jiangsu, Peoples R China

[3] Jiangsu Prov Hosp Integrat Chinese & Western Med, Jiangsu Prov Acad Tradit Chinese Med, Dept Clin Lab, Nanjing 210028, Peoples R China

来源：

COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE | 2022年 / 2022卷

关键词：

EFFICACY; COLITIS; METAANALYSIS; ANTIOXIDANT; ANTICANCER; PREBIOTICS; HEALTH; IMPACT; IBD;

D O I：

10.1155/2022/1353724

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Objective. This study was to define the protective effect of purified Helvella leucopus polysaccharide (p-HLP) against dextran sulfate sodium- (DSS-) induced colitis. Methods. The novel p-HLP was isolated from Bachu mushroom through hot water extraction, ethanol precipitation, and column chromatography. Then, we evaluated the potential effects of p-HLP on colonic histopathology, inflammation, and microbiota composition in DSS-induced colitis mice. Results. p-HLP was a homopolysaccharide with an average molecular weight of 39.14 x 10(8) Da. Functionally, p-HLP significantly attenuated DSS-induced body weight loss and colon shortening. The histological score of the colon lesion was significantly decreased upon p-HLP treatment. Also, p-HLP treatment led to decreased expression of proinflammatory cytokines and mediators (IL-6, IL-1 beta and TNF-alpha, and COX-2 and iNOS) and increased expression of anti-inflammatory cytokine (IL-10) in the colon tissues. Illumina MiSeq sequencing revealed that p-HLP modulated the composition of the gut microbiota. Conclusion. p-HLP is a potent regulator that protects the lesions from DSS-induced colitis.

引用

页数：12

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