Bcl-3 is a novel biomarker of renal fibrosis in chronic kidney disease

被引：9

作者：

Chen, Ran ^{[1
]}

Wang, Lunshan ^{[2
]}

Liu, Sanhong ^{[3
]}

Chen, Xi ^{[1
]}

Hu, Yiming ^{[1
]}

Liu, Hanshao ^{[1
]}

Zhang, Haohao ^{[1
]}

Jiang, Yuhang ^{[1
]}

Wang, Qi ^{[1
]}

Ye, Deji ^{[1
]}

Li, Lingling ^{[1
]}

Liu, Dandan ^{[1
]}

Pan, Xiaorong ^{[4
]}

Wei, Lixin ^{[4
]}

Li, Xuemei ^{[5
]}

Zhang, Xiaoren ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Chinese Acad Sci, Sch Med, Key Lab Stem Cell Biol,Inst Hlth Sci,Shanghai Inst, Shanghai 200031, Peoples R China

[2] Chinese Peoples Liberat Army 105th Hosp, Clin Lab Dept, Hefei 230001, Anhui, Peoples R China

[3] ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China

[4] Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Tumor Immunol & Gene Therapy Ctr, Shanghai 200433, Peoples R China

[5] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Nephrol, Beijing 100723, Peoples R China

来源：

ONCOTARGET | 2017年 / 8卷 / 57期

基金：

中国国家自然科学基金;

关键词：

Bcl-3; renal fibrosis; chronic kidney disease; unilateral ureteral obstruction; biomarker; CANDIDATE PROTOONCOGENE BCL-3; KAPPA-B; OBSTRUCTIVE NEPHROPATHY; URETERAL OBSTRUCTION; ONCOPROTEIN BCL-3; P50; HOMODIMERS; MOUSE MODEL; INSIGHTS; CANCER;

D O I：

10.18632/oncotarget.21692

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Progressive renal fibrosis in chronic kidney disease (CKD) greatly contributes to end-stage renal failure and is associated with high mortality. The identification of renal fibrosis biomarkers for the diagnosis and the monitoring of disease progression in CKD is urgently needed. Whole-transcriptomic analysis of renal tissues in a unilateral ureteral obstruction (UUO) mouse model revealed that the mRNA level of Bcl-3, an atypical member of the NB family, was induced 6.3-fold 2 days after UUO. Compared with renal tissues in sham-operated mice, increases in Bcl-3 mRNA and protein in the renal tissues in the UUO model were accompanied with increases in other markers of renal fibrosis, including human epididymis protein 4 (HE4), a recently identified biomarker of renal fibrosis. Immunohistochemical analysis revealed that both Bcl-3 and HE4 were located in the plasma of renal tubule cells. Serum protein levels of Bcl-3 and HE4 rose with the development of renal fibrosis in UUO mouse model. We found that the serum protein levels of both HE4 and Bcl-3 were elevated in CKD patients compared with healthy controls. Moreover, a significant positive correlation between Bcl-3 and HE4 (r = 0.939, p < 0.0001) was observed in CKD patients. These data suggest that Bcl-3 can serve as a novel valuable biomarker of renal fibrosis in CKD.

引用

页码：97206 / 97216

页数：11

共 23 条

[21] Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease [J].