An improved synthesis of 5′-fluoro-5′-deoxyadenosines

被引：19

作者：

Ashton, TD ^{[1
]}

Scammells, PJ ^{[1
]}

机构：

[1] Monash Univ, Victorian Coll Pharm, Dept Med Chem, Parkville, Vic 3052, Australia

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 14期

关键词：

5; '-fluoroadenosine;

D O I：

10.1016/j.bmcl.2005.05.029

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthesis of 5'-fluoro-5'-deoxyadenosine (5'-FDA) and structurally similar compounds is generally a poor yielding process. This is attributed to the instability of the selected synthetic intermediates. Herein, we report a general synthesis of 5'-fluoro-5'-deoxy-N-6-substituted adenosines including a high yielding access to 5'-FDA. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：3361 / 3363

页数：3

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