Aberrant crypt foci as precursors in colorectal cancer progression

Colorectal cancer progression orignates when accumulated genetic and epigenetic alterations cause instability and a malignant phenotype. subsequent molecular pathway deregulation lead, to histopathologic changes that are clinically evident Lis aberrant crypt foci (ACF) and visualized by high-magnification chromoscopic colonoscopy. ACF are biomarkers of increased colorectal cancer risk, particularly, those wilh dysplastic features. Genetic profiling using genomic instability, loss of heterozygosity, and methylation analysis has revealed a minority population of ACF genotypically analogons to cancer.