Aberrant crypt foci as precursors in colorectal cancer progression

被引：59

作者：

Orlando, Frank A. ^{[1
]}

Tan, Dongfeng ^{[2
]}

Baltodano, Juan D. ^{[3
]}

Khoury, Thaer ^{[4
]}

Gibbs, John F. ^{[5
]}

Hassid, Victor J. ^{[6
]}

Ahmed, Bestoun H. ^{[6
]}

Alrawi, Sadir J. ^{[7
]}

机构：

[1] Univ Florida, Dept Surg, Gainesville, FL 32610 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA

[3] SUNY Upstate Med Univ, Div Gastroenterol, Syracuse, NY USA

[4] Roswell Pk Canc Inst, Dept Pathol, Buffalo, NY USA

[5] Roswell Pk Canc Inst, Div Surg Oncol, Buffalo, NY USA

[6] Univ Florida, Dept Surg, Jacksonville, FL USA

[7] Canc Ctr Jacksonville, Jacksonville, FL USA

来源：

JOURNAL OF SURGICAL ONCOLOGY | 2008年 / 98卷 / 03期

关键词：

crypt; gene; colorectal; colonoscopy; methylation;

D O I：

10.1002/jso.21106

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Colorectal cancer progression orignates when accumulated genetic and epigenetic alterations cause instability and a malignant phenotype. subsequent molecular pathway deregulation lead, to histopathologic changes that are clinically evident Lis aberrant crypt foci (ACF) and visualized by high-magnification chromoscopic colonoscopy. ACF are biomarkers of increased colorectal cancer risk, particularly, those wilh dysplastic features. Genetic profiling using genomic instability, loss of heterozygosity, and methylation analysis has revealed a minority population of ACF genotypically analogons to cancer.

引用

页码：207 / 213

页数：7

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