Toward site-specific, homogeneous and highly stable fluorescent silver nanoclusters fabrication on triplex DNA scaffolds

被引：79
|
作者：
Feng, Lingyan [1 ,2 ,3 ]
Huang, Zhenzhen [1 ,2 ,3 ]
Ren, Jinsong [1 ,2 ,3 ]
Qu, Xiaogang [1 ,2 ,3 ]
机构：
[1] Chinese Acad Sci, Biol Chem Lab, Changchun Inst Appl Chem, Changchun 130022, Peoples R China
[2] Chinese Acad Sci, State Key Lab Rare Earth Resources Utilizat, Changchun Inst Appl Chem, Changchun 130022, Peoples R China
[3] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
来源：
NUCLEIC ACIDS RESEARCH | 2012年 / 40卷 / 16期
基金：
中国国家自然科学基金;
关键词：
IN-VITRO; NANOPARTICLES; RECOGNITION; BEHAVIOR;
D O I：
10.1093/nar/gks387
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A new strategy to create site-specific, homogeneous, and bright silver nanoclusters (AgNCs) with high-stability was demonstrated by triplex DNA as template. By reasonable design of DNA sequence, homogeneous Ag-2 cluster was obtained in the predefined position of CG.C+ site of triplex DNA. This strategy was also explored for controlled alignment of AgNCs on the DNA nanoscaffold. To the best of our knowledge, this was the first example to simultaneously answer the challenges of excellent site-specific nucleation and growth, homogeneity and stability against salt of DNA-templated AgNCs.
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收藏
页数：9
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