Flow cytometry evaluation of infection-related biomarkers in febrile subjects in the emergency department

被引：13

作者：

Bourgoin, Penelope ^{[1
,2
]}

Lediagon, Guillaume ^{[3
]}

Arnoux, Isabelle ^{[4
]}

Bernot, Denis ^{[4
]}

Morange, Pierre-Emmanuel ^{[2
,4
]}

Michelet, Pierre ^{[3
]}

Malergue, Fabrice ^{[1
]}

Markarian, Thibaut ^{[3
]}

机构：

[1] Beckman Coulter Life Sci Immunotech, Dept Res & Dev, 130 Ave Lattre Tassigny, F-13009 Marseille, France

[2] Aix Marseille Univ, C2VN INSERM INRA, 27 Blvd Jean Moulin, F-13385 Marseille, France

[3] La Timone Hosp, AP HM, Adult Emergency Unit, 264 Rue St Pierre, F-13385 Marseille, France

[4] La Timone Hosp, AP HM, Hematol Lab, 264 Rue St Pierre, F-13385 Marseille, France

来源：

FUTURE MICROBIOLOGY | 2020年 / 15卷 / 03期

关键词：

bacterial infection; emergency department; fever; flow cytometry; viral infection; C-REACTIVE PROTEIN; BACTERIAL-INFECTION; EARLY-DIAGNOSIS; EXPRESSION; ACCURACY; MARKERS; CD64; PROCALCITONIN; DIFFERENTIATE; EXAMPLE;

D O I：

10.2217/fmb-2019-0256

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Aim: In an Emergency Department (ED), the etiological identification of infected subjects is essential. 13 infection-related biomarkers were assessed using a new flow cytometry procedure. Materials & methods: If subjects presented with febrile symptoms at the ED, 13 biomarkers' levels, including CD64 on neutrophils (nCD64) and CD169 on monocytes (mCD169), were tested and compared with clinical records. Results: Among 50 subjects, 78% had bacterial infections and 8% had viral infections. nCD64 showed 82% sensitivity and 91% specificity for identifying subjects with bacterial infections. mCD169, HLA-ABC ratio and HLA-DR on monocytes had high values in subjects with viral infections. Conclusion: Biomarkers showed promising performances to improve the ED's infectious stratification.

引用

页码：189 / 201

页数：13

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