Study of Simvastatin Self-Association Using Electrospray-Ionization Mass Spectrometry

被引:2
作者
Vetrova, E. V. [1 ]
Lekar, A. V. [1 ]
Filonova, O. V. [1 ]
Borisenko, S. N. [1 ]
Maksimenko, E. V. [1 ]
Borisenko, N. I. [1 ]
机构
[1] Southern Fed Univ, Inst Phys & Organ Chem, Rostov Na Donu 344090, Russia
关键词
simvastatin; electrospray-ionization mass spectrometry; simvastatin complexation; TRITERPENE GLYCOSIDES; COMPLEXES; MIXTURES;
D O I
10.1007/s10812-015-0110-3
中图分类号
O433 [光谱学];
学科分类号
0703 ; 070302 ;
摘要
Self-association of simvastatin, which is widely used to treat coronary heart disease, was investigated using electrospray-ionization mass spectrometry. Formation of simvastatin self-associates in various solvents was demonstrated using mass spectrometry. Solvation effects were shown to play a special role in the formation of the self-associates. Self-associates containing from two to fi ve simvastatin molecules were detected in mass spectra of an aqueous MeOH (20%) solution of simvastatin. The formation of simvastatin self-associates could compete with the complexation of supramolecular structures during the synthesis of new generation drugs.
引用
收藏
页码:337 / 342
页数:6
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