Study of Simvastatin Self-Association Using Electrospray-Ionization Mass Spectrometry

被引：2

作者：

Vetrova, E. V. ^{[1
]}

Lekar, A. V. ^{[1
]}

Filonova, O. V. ^{[1
]}

Borisenko, S. N. ^{[1
]}

Maksimenko, E. V. ^{[1
]}

Borisenko, N. I. ^{[1
]}

机构：

[1] Southern Fed Univ, Inst Phys & Organ Chem, Rostov Na Donu 344090, Russia

来源：

JOURNAL OF APPLIED SPECTROSCOPY | 2015年 / 82卷 / 03期

关键词：

simvastatin; electrospray-ionization mass spectrometry; simvastatin complexation; TRITERPENE GLYCOSIDES; COMPLEXES; MIXTURES;

D O I：

10.1007/s10812-015-0110-3

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

Self-association of simvastatin, which is widely used to treat coronary heart disease, was investigated using electrospray-ionization mass spectrometry. Formation of simvastatin self-associates in various solvents was demonstrated using mass spectrometry. Solvation effects were shown to play a special role in the formation of the self-associates. Self-associates containing from two to fi ve simvastatin molecules were detected in mass spectra of an aqueous MeOH (20%) solution of simvastatin. The formation of simvastatin self-associates could compete with the complexation of supramolecular structures during the synthesis of new generation drugs.

引用

页码：337 / 342

页数：6

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