Copper-Catalyzed C-H Oxidation/Cross-Coupling of α-Amino Carbonyl Compounds

被引：145

作者：

Wu, Ji-Cheng ^{[1
,2
]}

Song, Ren-Jie ^{[1
]}

Wang, Zhi-Qiang ^{[1
,2
]}

Huang, Xiao-Cheng ^{[1
,2
]}

Xie, Ye-Xiang ^{[1
]}

Li, Jin-Heng ^{[1
]}

机构：

[1] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China

[2] Hunan Normal Univ, Minist Educ, Key Lab Chem Biol & Tradit Chinese Med Res, Changsha 410081, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 14期

关键词：

amines; copper; heterocycles; oxidation; synthetic methods; TERMINAL ALKYNES; ASYMMETRIC-SYNTHESIS; OXIDATIVE AMIDATION; AEROBIC OXIDATION; ACID DERIVATIVES; DIRECT ARYLATION; NITROGEN ATOM; BONDS; ESTERS; ARYLGLYCINES;

D O I：

10.1002/anie.201109027

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Keeping options open: The new and mild title reaction involving indoles selectively furnishes 1 and 2 with the aid of tert-butyl hydroperoxide (TBHP). The method represents the first example of a copper-catalyzed α arylation of α-amino carbonyl substrates leading to α-aryl α-imino and α-aryl α-oxo carbonyl compounds using a C-H oxidation strategy. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：3453 / 3457

页数：5

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