SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF ACETOXYBENZOYL THIOUREAS WITH ARYL AND AMINO ACID SIDE CHAINS

被引：22

作者：

Ngaini, Zainab ^{[1
]}

Arif, Maya Asyikin Mohd ^{[1
]}

Hussain, Hasnain ^{[2
]}

Mei, Er Su ^{[1
]}

Tang, Donna ^{[1
]}

Kamaluddin, Dyg Halimatulzahrah Abang ^{[1
]}

机构：

[1] Univ Malaysia Sarawak, Dept Chem, Fac Resource Sci & Technol, Kota Samarahan 94300, Sarawak, Malaysia

[2] Univ Malaysia Sarawak, Dept Mol Biol, Fac Resource Sci & Technol, Kota Samarahan 94300, Sarawak, Malaysia

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2012年 / 187卷 / 01期

关键词：

Thiourea; aspirin; amino acid; antibacterial activity; DERIVATIVES; ASPIRIN;

D O I：

10.1080/10426507.2011.562398

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of acetoxybenzoylthioureas derivatives with aryl and amino acid ester side chains were prepared by reaction of acetoxybenzoyl isothiocyanate, an acyloxy benzyl ester-based derivative of aspirin, with aryl amines or amino-functionalized amino acids with overall yields of 46-73%. The products that display a thiourea segment as a linker showed improved antibacterial properties in comparison with aspirin. The structures of the synthesized compounds were characterized by infra red spectroscopy, C-13 nuclear magnetic resonance (NMR), and H-1 NMR spectroscopy. The compounds were screened for their antibacterial activity by using gram-negative bacteria (E. coli ATCC 8739). [2-(phenylcarbamothioylcarbamoyl)phenyl] acetate showed the highest antibacterial activity against E. coli compared with other synthesized compounds.

引用

页码：1 / 7

页数：7

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