Cutting edge: Soluble IL-6R is produced by IL-6R ectodomain shedding in activated CD4 T cells

被引：145

作者：

Briso, Eva M. ^{[1
]}

Dienz, Oliver ^{[1
]}

Rincon, Mercedes ^{[1
]}

机构：

[1] Univ Vermont, Dept Med, Immunobiol Div, Immunobiol Program, Burlington, VT 05405 USA

来源：

JOURNAL OF IMMUNOLOGY | 2008年 / 180卷 / 11期

关键词：

D O I：

10.4049/jimmunol.180.11.7102

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IL-6 trans-signaling via the soluble IL-6R (sIL-6R) plays an important role in the progression of several autoimmune diseases and cancer by providing IL-6-responsiveness to cells lacking IL-6R. However, the potential sources of sIL-6R are less understood. In this study we show that sIL-6R is produced by both naive and memory CD4 T cells upon TCR activation. The production of sIL-6R by activated CD4 T cells is mediated by shedding of the membrane-bound IL-6R, and this process correlates with the expression of the metalloproteinase ADAM17 in these cells. In contrast to CD4 T cells, CD8 T cells do not express ADAM17 and their production of sIL-6R is negligible. Thus, during an immune response CD4 T cells are an important source of sIL-6R. Production of sIL-6R by auto-reactive CD4 T cells may contribute to their role in the development of autoimmune disease by conferring IL-6-responsiveness to cells lacking IL-6R such as synoviocytes.

引用

页码：7102 / 7106

页数：5

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