Cutting edge: Soluble IL-6R is produced by IL-6R ectodomain shedding in activated CD4 T cells

被引：145
作者：
Briso, Eva M. [1 ]
Dienz, Oliver [1 ]
Rincon, Mercedes [1 ]
机构：
[1] Univ Vermont, Dept Med, Immunobiol Div, Immunobiol Program, Burlington, VT 05405 USA
来源：
JOURNAL OF IMMUNOLOGY | 2008年 / 180卷 / 11期
关键词：
D O I：
10.4049/jimmunol.180.11.7102
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
IL-6 trans-signaling via the soluble IL-6R (sIL-6R) plays an important role in the progression of several autoimmune diseases and cancer by providing IL-6-responsiveness to cells lacking IL-6R. However, the potential sources of sIL-6R are less understood. In this study we show that sIL-6R is produced by both naive and memory CD4 T cells upon TCR activation. The production of sIL-6R by activated CD4 T cells is mediated by shedding of the membrane-bound IL-6R, and this process correlates with the expression of the metalloproteinase ADAM17 in these cells. In contrast to CD4 T cells, CD8 T cells do not express ADAM17 and their production of sIL-6R is negligible. Thus, during an immune response CD4 T cells are an important source of sIL-6R. Production of sIL-6R by auto-reactive CD4 T cells may contribute to their role in the development of autoimmune disease by conferring IL-6-responsiveness to cells lacking IL-6R such as synoviocytes.
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页码：7102 / 7106
页数：5
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