Palladium-Catalyzed Direct Arylation of Polysubstituted Benzofurans

被引：60

作者：

Carrer, Amandine ^{[1
,2
]}

Brinet, Dimitri ^{[1
,2
]}

Forent, Jean-Claude ^{[1
,2
]}

Rousselle, Patricia ^{[3
]}

Bertounesque, Emmanuel ^{[1
,2
]}

机构：

[1] CNRS UMR 176, F-75248 Paris, France

[2] Inst Curie, Ctr Rech, F-75248 Paris, France

[3] CNRS UMR 5086, Inst Biol & Chim Prot, F-69367 Lyon, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 77卷 / 03期

关键词：

PROTON-ABSTRACTION MECHANISM; C-H FUNCTIONALIZATION; SOLID-PHASE SYNTHESIS; ARYL BOND FORMATION; EFFICIENT SYNTHESIS; C-2; ARYLATION; ACID; DERIVATIVES; CYCLIZATION; ANNULATION;

D O I：

10.1021/jo202060k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient access to 2-substituted 3-arylbenzofurans through a palladium-catalyzed C3 direct arylation of 2-substituted benzofurans with aryl bromides is described. The scope and limitation of this reaction was studied. The method tolerates a variety of functional groups on the aryl halide and has been successfully extended to polysubstituted benzofurans to obtain the corresponding 3-arylbenzofurans with good to excellent yields.

引用

页码：1316 / 1327

页数：12

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