Heat shock proteins in oncology: Diagnostic biomarkers or therapeutic targets?

被引:158
作者
Khalil, Ashraf A. [1 ]
Kabapy, Nihal F. [1 ]
Deraz, Sahar F. [1 ]
Smith, Christopher [2 ]
机构
[1] Inst Genet Engn & Biotechnol, Dept Prot Technol, Alexandria, Egypt
[2] Manchester Metropolitan Univ, Manchester M14 6HR, Lancs, England
来源
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2011年 / 1816卷 / 02期
关键词
HUMAN HEPATOCELLULAR-CARCINOMA; BREAST-CANCER CELLS; NEGATIVE REGULATION; TRANSCRIPTIONAL RESPONSE; MOLECULAR CHAPERONES; RHEUMATOID-ARTHRITIS; MEDIATED APOPTOSIS; DOWN-REGULATION; OVARIAN-CANCER; LUNG-CANCER;
D O I
10.1016/j.bbcan.2011.05.001
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Heat shock proteins (HSP) are a family of proteins induced in cells exposed to different insults. This induction of HSPs allows cells to survive stress conditions. Mammalian HSPs have been classified into six families according to their molecular size: HSP100, HSP90, HSP70, HSP60, HSP40 and small HSPs (15 to 30 kDa) including HSP27. These proteins act as molecular chaperones either helping in the refolding of misfolded proteins or assisting in their elimination if they become irreversibly damaged. In recent years, proteomic studies have characterized several different HSPs in various tumor types which may be putative clinical biomarkers or molecular targets for cancer therapy. This has led to the development of a series of molecules capable of inhibiting HSPs. Numerous studies speculated that over-expression of HSP is in part responsible for resistance to many anti-tumor agents and chemotherapeutics. Hence, from a pharmacological point of view, the co-administration of HSP inhibitors together with other anti-tumor agents is of major importance in overcoming therapeutic resistance. In this review, we provide an overview of the current status of HSPs in autoimmune, cardiovascular, and neurodegenerative diseases with special emphasis on cancer. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码:89 / 104
页数:16
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